To determine the role of the hepatic sinusoidal endothelium in the hepatic disposition of liposomal doxorubicin, we compared the hepatic pharmacokinetics of doxorubicin hydrochloride and the pegylated, liposomal formulation of doxorubicin (Caelyx). The multiple indicator-dilution technique and electron microscopy were used to study the disposition of doxorubicin and liposomal doxorubicin in the...

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Doxorubicin as a chemotherapy agent is most widely used in cancer treatment. Long-term use at predetermined dose has side effect, namely cardiotoxicity. Doxorubicin-induced cardiotoxicity considered to be caused by reactive oxygen species (ROS), which also characterized increasing CK-MB enzyme levels the blood. To reduce impact of doxorubin-induced toxicity, study was conducted on natural antio...

Tumor-selective delivery of doxorubicin by a prostate-specific antigen (PSA)-targeted peptide conjugate prodrug of doxorubicin was demonstrated in a nude mouse xenograft model of human prostate cancer. The prodrug (referred to as doxorubicin conjugate) contains doxorubicin linked to a seven-amino acid peptide conjugate that was designed to increase delivery of doxorubicin to tumor sites through...

Introduction: Doxorubicin is one of the chemotherapy drugs that have harmful effects on blood hematology. Blood hematological diseases are caused by its adverse and anticancer properties. The antioxidant properties several plants been reported to be closely related reduced toxicity in Andaliman (Zanthoxylum acanthopodium) ethanolic extract (AEE) thought reduce doxorubicin due secondary metaboli...

Background: Many men in the world are infertile at reproductive age. One of causes male infertility is side effects chemotherapy drugs. Doxorubicin (DOX) a tetracycline used that has been shown to have adverse on testicular tissue. Objectives: The simultaneous effect high-intensity aerobic exercise and crocin (Cr) consumption doxorubicin-induced tissue not studied. Therefore, aim this study was...

objective: doxorubicin (dox) is a broad spectrum chemotherapeutic agent used in the treatment of several malignancies. the use of dox in clinical chemotherapy has been restricted due to its diverse toxicities, including reproductive toxicity. crataegus monogyna (c. monogyna) is one of the oldest medicinal plants that have been shown to be cytoprotective because of scavenging free radicals. the ...

The comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes was evaluated in rats at a dose of 6 mg/kg i.v. Doxorubicin was entrapped in cardiolipin liposomes by using 11.2 mumol of drug, 5.6 mumol of cardiolipin, 28.5 mumol of phosphatidylcholine, 19.5 mumol of cholesterol, and 11.1 mumol of stearylamine. The peak plasma concentration with free doxor...