objectives: down syndrome is the most common chrosomal disorder in which the fine and gross motor skills due to lack of proper sensory experience are disturbed. the role of dexterity in activity of daily living, interaction with environment and independency is quiet crucial in down syndrome. therefore, the aim of this study was to investigate the effects of simultaneous application of superfici...

To assess the nature of top-down perceptual processes without contamination from bottom-up input, this functional MRI study investigated face detection in pure noise images. Greater activation was revealed for face versus nonface responses in the fusiform face area, but not in the occipital face area. Across participants, positive correlations were found for the degree of greater face-detection...

Overview: In recent years, researchers have increasingly emphasized the role of developmental processes in the formation of behavioral phenotypes in young children with neurogenetic disorders (Edgin et al., 2015; Fidler, 2005; Fidler, Lunkenheimer & Hahn, 2011; Karmiloff-Smith, 2011). From this perspective, early developmental profiles may facilitate or constrain a child’s development, and can ...

Evidence suggests that the neural system associated with face processing is a distributed cortical network containing both bottom-up and top-down mechanisms. While bottom-up face processing has been the focus of many studies, the neural areas involved in the top-down face processing have not been extensively investigated due to difficulty in isolating top-down influences from the bottom-up resp...

Research in Down syndrome has substantially progressed in the understanding of the effect of gene overexpression at the molecular level, but there is a paucity of information on the ultimate consequences on overall brain functional organization. We have assessed the brain functional status in Down syndrome using functional connectivity MRI. Resting-state whole-brain connectivity degree maps wer...

Alternations of up and down can be seen across many different levels during sleep. Neural firing-rates, synaptic markers, molecular pathways, and gene expression all show differential up and down regulation across brain areas and sleep stages. And also the hallmarks of sleep - sleep stage specific oscillations - are characterized themselves by up and down as seen within the slow oscillation or ...

Cortical rhythms have been thought to play crucial roles in our cognitive abilities. Rhythmic activity in the beta frequency band, around 20 Hz, has been reported in recent studies that focused on neural correlates of attention, indicating that top-down beta rhythms, generated in higher cognitive areas and delivered to earlier sensory areas, can support attentional gain modulation. To elucidate...