Messing J, Crea R & Seeburg P H. A system for shotgun DNA sequencing. Nucl. Acid. Res. 9:309-21, 1981. [Dept. Bacteriology, Univ. California, Davis, CA] Messing J & Vieira J. A new pair of M13 vectors for selecting either DNA strand of double digest restriction fragments. Gene 19:269-76, 1982. [Dept. Biochemistry, Univ. Minnesota, St. Paul, MN] Yanisch-Perron C, Vieira J & Messing J. Improved M...

In This Issue In This Issue he ER is a site of both synthesis and quality control. Rejected, improperly folded proteins are destroyed by a well-characterized machinery (the ER-associated degradation [ERAD] pathway) in the cytosol and ER membrane that extracts and chews up any unfolded proteins. But the mechanisms for recognizing unfolded proteins as targets for destruction are less well charact...

Differences in E. coli O157:H7 strain colonization and shedding patterns in cattle American researchers conducted oral challenge studies with three different genotypes of E. coli O157:H7 in cattle to determine the genotypic variability in shedding frequencies and concentrations and the extent of contamination of the environment. Four groups of Holstein steers each were orally challenged with 10...

The goal of this study was to describe patterns in the dynamics of families of talented junior athletes throughout their development. Parents, athletes, and siblings from four families were interviewed. The interviews focused on how family members adapted to the motivation, effort, and resource demands that often constrain the development of talent in sport. The results permitted the identifica...

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The Hypertext Transfer Protocol (HTTP) provides a simple challenge-response authentication mechanism that may be used by a server to challenge a client request and by a client to provide authentication information. This document defines the HTTP Digest Authentication scheme that can be used with the HTTP authentication mechanism.