We investigated a proposed synergistic effect of deoxynivalenol (DON) and lipopolysaccharides (LPS) on small intestinal architecture and epithelial barrier integrity in pigs. Crypt depth and intestinal cell proliferation were analyzed, as well as expression of zonula occludens protein-1 (ZO-1) and β-catenin of the apical junction complex along the small intestine. Barrows (26.2±4.1 kg) were fed...

Coggin, J. H., Jr. (The University of Chicago, Chicago, Ill.), and W. R. Martin. 6-Diazo-5-oxo-l-norleucine inhibition of Escherichia coli. J. Bacteriol. 89:1348-1353. 1965.-The glutamine analogue 6-diazo-5-oxo-l-norleucine (DON) induced filaments and spheroplasts in Escherichia coli during the transition of sensitive populations to a state of resistance. Resistance developed at a frequency sug...

? age of three years, had a violent fever, attended with great pain in his head apd ftor mach, and tenfe painful fwellings of his feet; and ancles, which continued upwards of a month. About two years after, he had another attack of a fimilar feyer, when the fwellings and pain remained upon him for fix weeks, leaving him at length in a very languid and debilitated ftate. The chorea fan?ti viti a...

The glutamine analogue, 6-diazo-5-oxo-L-norleucine (DON), has been shown to inhibit biosynthesis of purines and glycosaminoglycans, presumably by blocking the glutamine-dependent steps in the biosynthetic pathways. The teratogenic potential of DON on the developing mouse limb-bud in vivo and in vitro was studies in an attempt to discriminate whether DON is exerting its teratogenic effect by int...

Most nitrogen (N) assimilation in lake and marine ecosystems is often subsequently released via autochthonous dissolved organic nitrogen (DON) production, but autochthonous DON production has yet to be quantified in flowing waters. We measured in-stream DON production following 24 h 15N-nitrate (NO{3 ) tracer additions in 36 headwater streams, a subset of sites from the second Lotic Intersite N...

The mycotoxin deoxynivalenol (DON), one of the most common food contaminants, primarily targets the gastrointestinal tract to affect animal and human health. This study was conducted to examine the protective function of glutamic acid on intestinal injury and oxidative stress caused by DON in piglets. Twenty-eight piglets were assigned randomly into 4 dietary treatments (7 pigs/treatment): 1) u...

objective(s):the present study investigated the antidiabetic and hypolipidemic properties of dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. materials and methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of d.  aucheri (100, 200 and 400 mg/kg bw) or glibenclamide (0.25 mg/kg) f...

Donald C. Ellison, Pasquale Blasi, Stefano Gabici (a) Physics Dept., North Carolina State Univ., Raleigh, NC 27695, U.S.A. (b) High Energy Astrophysics Group, INAF, Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125, Firenze, Italy (c) Humboldt Fellow, Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany Presenter: Don Ellison (don [email protected]), usa...