BACKGROUND In this study, we characterize the morbidity at the donor-site of partial second toe pulp free flaps in terms of wound management as well as long-term outcomes. METHODS A single-institutional retrospective review was performed for patients who had undergone partial second toe pulp free flap transfer to the fingertip. Patient charts were reviewed for infection, skin necrosis, wound ...

Artificial neural networks have been applied to the prediction of splice site location in human pre-mRNA. A joint prediction scheme where prediction of transition regions between introns and exons regulates a cutoff level for splice site assignment was able to predict splice site locations with confidence levels far better than previously reported in the literature. The problem of predicting do...

BACKGROUND The purpose of this study was to evaluate long-term functional donor site morbidity following ulnar forearm flap harvest taking both subjective and objective criteria into consideration. METHODS In this retrospective analysis, 61 patients were evaluated for subjective and objective donor site morbidity 3 to 164 months after flap harvest, and the Disabilities of Arm, Shoulder, and H...

BACKGROUND The radial forearm free flap (RFFF) is the most commonly used free flap in head and neck reconstructive surgery. However, despite excellent results with respect to the site of reconstruction, donor site morbidity cannot be neglected. This review summarizes the current state of knowledge and analyzes the level of evidence with regard to perioperative management of the reduction of RFF...

OBJECTIVES Full thickness skin grafts (FTSG) offer several advantages; they are esthetically superb, have less postoperative shrinkage, and offer minimal postoperative pain and scar formation at the donor site. As a donor site of FTSG, the groin offers a relatively large area of skin with high elasticity. The aim of this study was to evaluate FTSG from the groin for reconstruction in oral and m...

Alternative splicing of the precursor mRNA (pre-mRNA) of human parvovirus B19 (B19V) plays a key role in posttranscriptional regulation of B19V gene expression. We report that the central exon of the B19V pre-mRNA is defined by three GAA motif-containing exonic splicing enhancers and a G/GU-rich intronic splicing enhancer that lies adjacent to the second donor site. Moreover, targeting of morph...

In recent years, there has been increasing interest by reconstructive surgeons in improving the aesthetic and functional outcomes of donor sites. As the success rate of free tissue transfers has exceeded more than 95% in most microsurgical centers, more emphasis can be shifted to the donor site. However, morbidities of donor sites can occur not only in free tissue transfers, but in locoregional...

A limited clinical trial on split-thickness skin graft donor sites was conducted in 15 consecutive patients to assess the action of MEBO compared with the conventional Sofra-Tulle (Roussel Laboratories Ltd., Uxbridge, UK) split-thickness skin graft donor site dressing used in our service. All patients included in the study were white, with Fitzpatrick skin types II and III (age range, 5–65 year...

abstract   the perfect method for breast reconstruction would be safe, reliable, reproducible, applicable to all patients, and would have no donor site morbidity. the ideal reconstructed breast would provide symmetric, permanent, and natural results. there has been development and refinement of autogenous methods of breast reconstruction throughout the literature. the tram flap remains the most...

OBJECTIVE Describe the use of the scalp as a donor site for split thickness skin grafts in otologic surgery. MATERIALS AND METHODS Review of the literature with detailed description of surgical technique and authors' experience. RESULTS One hundred and forty- four scalp split thickness skin grafts were obtained between 2007 and 2011. No significant complications were observed with optimal c...