نتایج جستجو برای: dna polymorphism
تعداد نتایج: 593379 فیلتر نتایج به سال:
Objective(s) The Sst-I polymorphic site on the 3' untranslated region of the apo CIII gene, has been previously reported to be associated with hypertriglyceridemia. The aim of the present study was to explore the association between Sst-I polymorphism with plasma lipid and lipoprotein levels in hyperlipidemic (HLP) patients from Semnan province, Iran. Materials and Methods Genomic DNA was pr...
Endometriosis is a debilitating disorder, defined as the presence of endometrial gland and stroma outside of the uterus. It may affect angiogenesis and vascular endothelial growth factor (VEGF) is one of the angiogenic factors that plays an important role in both physiological and pathological angiogenesis. The present study aimed to evaluate the association of VEGF -2549 insertion/deletion (I/...
Introduction: The importance of scientific research in prevention of drug addiction is obvious. The main site of drug action is the brain. Mu receptor is the first place of drug action. In this study, the rate of mu receptor gene single nucleotide polymorphism (SNP) was compared in addicts and non-addicts. Methods: In this study AA, AG and AA polymorphism of mu receptor gene was investigated i...
Background: Breast cancer is one of the most common cancers among women worldwide. Tumor protein 53 (TP53) and its regulator the mouse double murine 2 (MDM2) have important roles in tumorigenesis by playing key roles in cell division and response to DNA damage. MDM2 SNP309 T>G (rs2279744) polymorphism in the promoter region of MDM2 gene can cause dysfunction and inactivation of TP53 which promo...
OBJECTIVE The present study evaluated the association between lactotransferrin (LTF) gene polymorphism (exon 2, A/G, Lys/Arg) and dental caries. MATERIAL AND METHODS A convenience sample of 110 individuals, 12 years old, was divided into: group 1, 48 individuals without caries experience (DMFT=0), and group 2, 62 subjects with caries experience (DMFT>or=1). DNA was obtained from a mouthwash w...
among the lesions induced by chemotherapeutic drugs, dna double-strand breaks (dsb) are considered the most serious ones that can result in cell death, if it is not properly repaired. homologous recombination (hr) pathway is the main system for dsb repair and xrcc3 has a key role in this pathway. protein activity can be affected by the xrcc3 polymorphism. thus, in this study, the association be...
genetic diversity of red jabal barez red goat population was studied based on eight microsatellite markers consist bm1312, maf64, ilsts034, ilsts059, orafcb20, il2ra, lscv24 and lscv11. blood sample extracted of 100 red jabal barez goats were randomly collected from 10 farms and dna was isolated using the diatom dna prep kit. the pcr reactions were successfully done and all loci showed suitable...
Colorectal cancer (CRC) is one of the common causes of cancer death in Iranian population. Both genetic and epigenetic changes have been implicated in CRC pathogenesis. DACT2 gene as one of the WNT signaling pathway inhibitor was shown to display tumor suppressor activity in many cancers. The aim of present study was to investigate the methylation status of DACT2 gene and its ...
Construction of a genetic linkage map is necessary to apply marker-assisted selection tools in a crop improvement program. Except for the recent studies from two laboratories, most of the previous studies have shown little or no DNA polymorphism in cultivated groundnut (Arachis hypogaea L.). In the present study, 70 selected genotypes, representing variability for several morphological, physiol...
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