Duchenne muscular dystrophy (DMD) is caused by genetic deficiency of dystrophin and characterized by massive structural and functional changes of skeletal muscle tissue, leading to terminal muscle failure. We recently generated a novel genetically engineered pig model reflecting pathological hallmarks of human DMD better than the widely used mdx mouse. To get insight into the hierarchy of molec...

Dynamic mode decomposition (DMD) is an Arnoldi-like method based on the Koopman operator. It analyzes empirical data, typically generated by nonlinear dynamics, and computes eigenvalues and eigenmodes of an approximate linear model. Without explicit knowledge of the dynamical operator, it extracts frequencies, growth rates, and spatial structures for each mode. We show that expansion in DMD mod...

The DMD (Digital Micromirror Device) has an important future in both ground and space based multi-object spectrometers. A series of laboratory measurements have been performed to determine the scattered light properties of a DMD. The DMD under test had a 17 m pitch and 1 m gap between adjacent mirrors. Prior characterization of this device has focused on its use in DLP (TI Digital Light Process...

BACKGROUND Left ventricular noncompaction (LVNC) describes deep trabeculations in the left ventricular (LV) endocardium and a thinned epicardium. LVNC is seen both as a primary cardiomyopathy and as a secondary finding in other syndromes affecting the myocardium such as neuromuscular disorders. The objective of this study is to define the prevalence of LVNC in the Duchenne Muscular Dystrophy (D...

Duchenne muscular dystrophy (DMD) is a progressive pediatric disorder that affects both muscle and brain. Children with DMD have mean IQ scores that are about one standard deviation lower than population means, with lower Verbal IQ than Performance IQ scores. For the present study, verbal skills and verbal memory skills were examined in males with DMD with the Clinical Evaluation of Language Fu...

Scene Background Initialization (SBI) is one of the challenging problems in computer vision. Dynamic mode decomposition (DMD) a recently proposed method to robustly decompose video sequence into background model and corresponding foreground part. However, this needs convert color image grayscale for processing, which leads neglect coupling information between three channels image. In study, we ...

Information on forage quality could help rangeland managers to select suitable grazing method to achieve higher animal performance without damage to vegetation. The aim of this study was to determine and compare the forage quality of S. yazdiana and S. tomentosa, which are the most important species of saline rangelands in Ardakan in Yazd province, Iran. These two species are grazed by goats an...

Duchenne muscular dystrophy (DMD), caused by mutations in the X-linked dystrophin gene (DMD), is characterized by fatal degeneration of striated muscles. Dilated cardiomyopathy is one of the most common lethal features of the disease. We deployed Cpf1, a unique class 2 CRISPR (clustered regularly interspaced short palindromic repeats) effector, to correct DMD mutations in patient-derived induce...

Duchenne muscular dystrophy (DMD) is an X-linked recessive progressive muscle degenerative disorder that causes dilated cardiomyopathy in the second decade of life in affected males. Dystrophin, the gene responsible for DMD, encodes full-length dystrophin and various short dystrophin isoforms. In the mouse heart, full-length dystrophin Dp427 and a short dystrophin isoform, Dp71, are expressed. ...

BACKGROUND Duchenne Muscular Dystrophy (DMD) is a recessive X-linked form of muscular dystrophy. Steroid therapy has clinical benefits for DMD patients, but the mechanism remains unclear. OBJECTIVE This study was designed to identify mRNAs and microRNAs regulated in Duchenne Muscular Dystrophy patients prior to and after steroid therapy. METHODS Genome wide transcriptome profiling of whole ...