The purpose of this paper is to analyze the relationship between alterations of splenic T-cell subpopulations and the amelioration of autoimmune diseases of MRL/MpTn-gld/gld mice (MRL/gld mice) after extended exposure to low-dose radiation. After the onset of disease, 4-month-old MRL/gld mice were exposed to doses of 0.05, 0.2, and 0.5 Gy/day for 4 weeks (5 days/week), for total doses of 1, 4, ...

The presence of similar nucleotide cofactor-binding domains in otherwise unrelated enzymes has been rationalized on the basis of the exon-shuffling model of protein evolution (Gilbert 1978). In the common case of enzymes which share a similar nucleotide-binding domain but exhibit different specificities for primary substrates, the degree of sequence similarity is restricted to small regions spe...

Let Cq be the non-commutative Laurent polynomial ring associated with a (n+1)×(n+1) rational quantum matrix q. sld(Cq)⊕HC1(Cq) universal central extension of Lie subalgebra sld(Cq) gld(Cq). We take algebra τ=gld(Cq)⊕HC1(Cq). Der(Cq) all derivations and consider τ˜=τ⋊Der(Cq), called full toroidal coordinated by tori. In this paper we get classification irreducible integrable modules finite dimen...

Pleiotropic developmental regulators have been repeatedly linked to the evolution of anatomical novelties. Known mechanisms include cis-regulatory DNA changes that alter regulator transcription patterns or modify target-gene linkages. Here, we examine the role of another form of regulation, translational control, in the repeated evolution of self-fertile hermaphroditism in Caenorhabditis nemato...

Globoid cell leukodystrophy (GLD), or Krabbe disease, is a rare and often fatal demyelinating disease caused by mutations in the galactocerebrosidase (galc) gene that result in accumulation of galactosylsphingosine (psychosine). We recently reported that the extracellular matrix (ECM) protease, matrix metalloproteinase-3, is elevated in GLD and that it regulates psychosine-induced microglial ac...

Successful meiotic progression of germ cells is crucial for gametogenesis. Defects in this process affect proper genetic transmission and sometimes lead to tumor formation in the germline. In Caenorhabditis elegans, the RNA-binding protein GLD-1 is essential for the meiotic development of oocytes. However, its role during spermatogenesis has not been understood. Here, we show that GLD-1 functio...

1 EGO-1, a putative RNA-directed RNA polymerase, promotes germline proliferation in parallel with GLP-1/Notch signaling and regulates the spatial organization of nuclear pore complexes and germline P granules in C. elegans ego-1 and germline proliferation 2 ego-1 and germline proliferation ego-1 and germline proliferation 3 ABSTRACT C. elegans EGO-1, a putative cellular RNA-directed RNA polymer...

In this paper, by following [3] and [4], we postpone to give an explicit estimation of Value-at-Risk and Expected Shortfall for Linear Portfolios when the risk Factors changes with mixture of generalized Laplace distributions. We therefore introduce the Delta-GLD-VaR, Delta-GLD-ES, Delta-MGLD-VaR and Delta-MGLD-ES. Note that, the GLD will give to us more flexibility to control the shape and fat...

A newly discovered autosomal recessive mutation, generalized lymphoproliferative disease (gld), in the C3H/HeJ strain of mice, determines the development of early onset massive lymphoid hyperplasia with autoimmunity. Significant lymph node enlargement is apparent as early as 12 wk of age. By 20 wk, lymph nodes are 50-fold heavier than those of coisogenic C3H/HeJ-+/+ mice. There is a concomitant...