In vitro dissolution tests are performed for new formulations to evaluate in vivo performance, which is affected by the change of gastrointestinal (GI) physiology, in the GI tract. Thus, those environmental changes should be introduced to an in vitro dissolution test. Many studies have successfully shown the improvement of in vitro-in vivo correlations (IVIVC) by introducing those physiological...

BACKGROUND Advances in techniques have left very few indications for open surgical extraction of urinary stones currently. These advances notwithstanding, the search continues for medical approaches to urinary stone management. In this study, we perform an in vitro study analyzing the efficiency and prospect of two new complex solutions in urological calcium phosphate calculi dissolution. MET...

The aim of this research project was to investigate a potential standardized test method to characterize the dissolution properties of numerous formulation types available for pulmonary delivery. A commercially available dissolution tester was adapted for use as a testing apparatus by the incorporation of a membrane-containing holder. The holder was designed to enclose previously air-classified...

Objective(s) The purpose of the present study was to use the solid dispersion (SD) technique to improve the dissolution rates of indomethacin (IMC). Materials and Methods IMC solid dispersions in PVP K30 and isomalt (GALEN IQ 990) were prepared using the solvent evaporation technique and a hot melt method in weight ratios of 2, 10 and 30% (IMC:PVP). Solid dispersions and physical mixtures we...

A fully coupled hydrological–mechanical–chemical (HMC) model is developed and applied to explain enigmatic spontaneous changes in permeability that develop within a fracture in limestone under simulated in situ conditions (Water Resour Res 2004;40:W03502). The water flow-through test was concurrently monitored for water and dissolved mineral mass efflux and periodically imaged by X-ray CT to pr...

objective(s) the purpose of the present study was to use the solid dispersion (sd) technique to improve the dissolution rates of indomethacin (imc). materials and methods imc solid dispersions in pvp k30 and isomalt (galen iq 990) were prepared using the solvent evaporation technique and a hot melt method in weight ratios of 2, 10 and 30% (imc:pvp). solid dispersions and physical mixtures were ...

Due to complexity and interplay of variable gastrointestinal conditions with matrix tablets which are predominantly erosion controlled it is often difficult to predict in vivo release profile [1]. Nascent gel layer of matrix tablets is prone to mechanical stress which is difficult to simulate in vitro. Present study describes approaches to establish a biorelevant in vitro test for evaluation of...

I discuss the possibility that the quark-gluon plasma at strong coupling admits a description in terms of a black hole in asymptotically anti-de Sitter space. Prepared for the Proceedings of Recent Developments in Gravity – NEB XIII, Thessaloniki, Greece, June 2008. Research supported in part by the US Department of Energy under grant DE-FG05-91ER40627. E-mail: [email protected]

The interchangeability between a generic and the respective reference drug is based on the concept of therapeutic equivalence between them, usually provided by evidence of pharmaceutical equivalence, bioequivalence, Good Manufacturing Practices (GMP), and quality control. This study aimed to evaluate the pharmaceutical equivalence between four brands of 500 mg aspirin tablets (two generic, G, a...