STUDY OBJECTIVE Intravenous (IV) prochlorperazine with diphenhydramine is superior to subcutaneous sumatriptan in the treatment of migraine patients presenting to the emergency department (ED). METHODS In this randomized, double-blind, placebo-controlled trial, after providing written informed consent, patients presenting to the ED with a chief complaint of migraine received a 500-mL bolus of...

BACKGROUND Sedating antihistamines may impair driving performance as seriously as alcohol. OBJECTIVE To compare the effects of fexofenadine, diphenhydramine, alcohol, and placebo on driving performance. DESIGN Randomized, double-blind, double-dummy, four-treatment, four-period crossover trial. SETTING The Iowa Driving Simulator. PARTICIPANTS 40 licensed drivers with seasonal allergic rh...

diphenhydramine, as an antihistamine drug is widely used for the treatment of allergies. however, being classified as an over the counter medication and the general belief on the low adverse effect profile of this drug has made it widely accessible to the families. recent reports of diphenhydramine intoxication and mortality, noticeably in children and infants have raised some serious concerns....

The aim of this work is to develop and validate simple, sensitive, selective and cost effective spectrophotometric methods for the determination of tetramisole hydrochloride in the presence of its alkali-induced degradation product without preliminary separation. These methods namely ratio difference [11,12], derivative ratio [13,14], mean centering [15,16] and continuous wavelet transform [17,...

BACKGROUND Antihistamines are among the most frequently used medications in the United States. Despite dramatically higher cost, second-generation antihistamines are replacing diphenhydramine because of the perception that they are not constrained by its sedating effects. OBJECTIVE We sought to examine, through meta-analytic procedures, the collective evidence regarding the sedating and perfo...

medical devices (urinary catheter or physical restraints), and blinded medical record extractions for diphenhydramine use. Results. Of the 426 patients, 114 (27%) received diphenhydramine during hospitalization and shared similar baseline characteristics including age, sex, delirium risk, and Mini-Mental State Examination scores compared with nonexposed patients. The diphenhydramine-exposed gro...

medical devices (urinary catheter or physical restraints), and blinded medical record extractions for diphenhydramine use. Results. Of the 426 patients, 114 (27%) received diphenhydramine during hospitalization and shared similar baseline characteristics including age, sex, delirium risk, and Mini-Mental State Examination scores compared with nonexposed patients. The diphenhydramine-exposed gro...

A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed and validated for the determination of donepezil in human plasma samples. Diphenhydramine was used as the internal standard. The collision-induced transition m/z 380 --> 91 was used to analyze donepezil in selected reaction monitoring mode. The signal intensity of the m/z 380 --> 91 transition was found to relate l...

A gas-liquid chromatographic procedure has been developed for measuring methyiphenidate and its metabolite, ritalinic acid, in urine. The unchanged drug is extracted into chloroform from alkalinized urine together with an internal standard, diphenhydramine. The solvent is removed, the residue dissolved in ethanol, and aliquots are injected into a gas-chromatographic Column containing 3% OV-1 7....

This study aimed to observe the clinical curative effect of penehyclidine hydrochloride (PHC) combined with hemoperfusion in treating acute severe organophosphorus pesticide poisoning. We randomly divided 61 patients with severe organophosphorus pesticide poisoning into an experimental group (N = 31) and a control group (N = 30), and we compared the coma-recovery time, mechanical ventilation ti...