background: glucantime ® is the first- line drug for the treatment of all forms of leishmaniasis. unfortunately, the prevalence of parasites becoming resistant to glucantime ® is increasing in several parts of the world including iran. as protein is the most important target for drugs in response to a variety of signals including drugs so, it seems expression protein patterns in sensitive and r...

We have modified one of the most useful methods of protein separation; namely, two dimensional gel electrophoresis (2-DE). This modified version of 2-DE is not only simpler and easier but also faster than all the currently available methods. In this method, isoelectric focusing is carried out in the first dimension using a vertical sodium dodecyl sulfate polyacrylamide gel electrop...

One third of all genes of various organisms encode membrane proteins, emphasizing their crucial cellular role. However, due to their high hydrophobicity, membrane proteins demonstrate low solubility and a high tendency for aggregation. Indeed, conventional two-dimensional gel electrophoresis (2-DE), a powerful electrophoretic method for the separation of complex protein samples that applies iso...