Dihydropyrimidine dehydrogenase (DPD) is responsible for degradation of the pyrimidines uracil and thymine and the inactivation of the chemotherapeutic agent 5-fluorouracil. DPD activity is highly variable in cancer populations, and this variation may influence the antitumor efficacy of 5-fluorouracil. However, little is known about the regulation of DPD mRNA expression in any tissues. Using a ...

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Numerical integration schemes based upon the Shardlow-splitting algorithm (SSA) are presented for dissipative particle dynamics (DPD) approaches at various fixed conditions, including a constant-enthalpy (DPD-H) method that is developed by combining the equations-of-motion for a barostat with the equations-of-motion for the constant-energy (DPD-E) method. The DPD-H variant is developed for both...

BACKGROUND Although 5-Fluorouracil (5-FU) is widely used in chemotherapeutic treatment for gallbladder cancer, there is little evidence of its effectiveness. Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are the major determinants of individual sensitivity to 5-FU, and the impact of TS and DPD expression on prognosis and 5-FU efficacy has been studied in gastrointestinal c...

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (FUra), one of the most widely used anticancer drugs. Previous studies from our laboratory demon strated the clinical importance of DPD in cancer patients (G. D. Heggie, J-P. Sommadossi, D. S. Cross, W. J. Muster, and R. B. Diasio. Cancer Res., 47: 2203-2206, 1987; B. E. Harris, R. ...

High frequency (HF) transmitters implemented with the multi-octave power amplifier (PA) are always faced problem of interfering harmonics because nonlinearity PA. In this paper, harmonic cancelation digital predistortion (HC-DPD) scheme is proposed and well discussed to cancel in-band intermodulation distortion (IMD) as out-of-band at same time. With filter-less scheme, bulky lossy filter banks...

BACKGROUND Dihydropyrimidine dehydrogenase (DPD) catalyzes the degradation of thymine, uracil, and the chemotherapeutic drug 5-fluorouracil. To identify patients suffering from complete or partial DPD deficiency and to identify pitfalls that can preclude the proper diagnosis of patients with partial DPD deficiency, a sensitive and accurate assay is necessary. METHODS The activity of DPD was m...

This application note describes system-level characterization and modeling techniques for radio frequency (RF) and microwave subsystem components. It illustrates their use in a mixed-signal, mixed-mode system-level simulation. The simulation uses an RF transmitter with digital predistortion (DPD) as an example system. Details of this complex system and performance data are presented. A similar ...

PURPOSE To determine whether 5-fluorouracil (5-FU) sensitivity is associated with the mRNA expressions of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and thymidine phosphorylase (TP) in patients with hepatocellular carcinoma (HCC) treated with 5-FU-based transarterial chemoembolization (TACE). METHODS Formalin-fixed, paraffin-embedded tumor specimens from 40 patients tre...