Effects of NiCl2 and sodium diethyldithiocarbamate (DDC) upon metallothionein (MT) concentrations were studied in liver and kidney of male Fischer rats. After injection of NiCl2 (0.75 mmol per kg, sc), hepatic MT concentration increased 2.6-fold at 6.5 hr and 8.2-fold at 17 hr; renal MT concentration increased 1.4-fold at 6.5 hr and 2.3-fold at 17 hr. Dose-related increases of MT concentrations...

A description of the physiology of sea-urchin spermatozoa requires, among other things, an explanation of two special characteristics which these spermatozoa possess. First, immediately after dilution, the Og uptake per spermatozoon is higher in a dilute than in a dense suspension. Secondly, the decline in sperm motility and fertilizing capacity is more rapid in a dilute than in a dense suspens...

It was the exciting message for HIV patients that inexpensive drug ditiocarb (diethyldithiocarbamate) was able to suppress the disease progression in clinical trials published 20 years ago in Lancet [1, 2]. Moreover, subsequent study (available in JAMA) confirmed ditiocarb as a potent drug against opportunistic infections in patients with symptomatic HIV disease [3]. Of course, such findings st...

The polymerization of isoprene through the use of benzyl N,N-diethyldithiocarbamate (BDC) as an iniferter was investigated. The monomer concentration used was kept constant at 2.8 mol/L while the BDC concentration was varied. The polymer product was characterized by Fourier Transform Infrared Spectroscopy (FTIR), Proton Magnetic Resonance (H-NMR), and Differential Scanning Calorimetry (DSC) and...

Diethyldithiocarbamate (DDTC) injected i.p. inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo. DDTC is more potent in inhibiting these effects of TPA than 16 other antioxidants, free radical scavengers, thiol-containing compounds,...

L-Tryptophan-2,3-dioxygenases (EC 1.13.1.12), purified to homogeneity from Pseudomonas acidovorans and from rat liver, have been shown to contain as bound cofactors, 2 g atoms copper and 2 moles of heme per mole of tetrameric enzyme. Kinetic and spectral studies, utilizing the metal complexing agents diethyldithiocarbamate (Cu2+ specific), bathocuproinesulfonate (Cu+ specific), and bathophenant...

A previously undetected pink copper protein has been isolated from human erythrocytes and purified by chromatographic procedures. The purified protein sedimented as a single symmetrical peak in the ultracentrifuge but minor impurities were detected by polyacrylamide disc electrophoresis. The apparent molecular weight was calculated to be approximately 32,000 by both Bio-Gel P-60 chromatography ...

BACKGROUND/AIM To investigate the effects of spermine NONOate in the cavernous tissue obtained from mice treated or untreated with sildenafil. MATERIALS AND METHODS We studied the effects of spermine NONOate on the tone and nitrergic relaxation responses of isolated mouse corpus cavernosum and compared them with sodium nitroprusside in the absence or presence of L-nitroarginine, hydroxocobala...