The Scientific Panel on Plant health, Plant protection products and their Residues (PPR Panel) of EFSA was asked if i) related to the increased incidence of tumours observed in various tissues in rats and mice following dichlorvos exposure, it is possible to identify a mode of action (for any of the tumours) and if so, is it possible to set a threshold for this effect; and ii) in considering an...

Aim: To investigate the Pesticide Residues (PRs) contamination of some cereals and determine their health risks in food chain Taraba North Geo-political region.
 Study Design: Maize, Millet, Rice Sorghum, soils were randomly collected from farmers’ field three (3) LGAs North.
 Place Duration Study: The samples Ardo-kola, Karim-lamido Zing State. They are processed at Laboratories Biol...

In fish, the role that cholinesterases (ChEs) play in tissues other than those implicated in neural activity, as well as the involvement of carboxylesterases (CbEs) and cytochrome P450 isoenzymes (CYPs) in drug metabolism needs investigation. For that, Senegalese sole (Solea senegalensis) specimens were selected for characterization of several type B esterases and hepatic CYPs in order to furth...

Introduction: Pesticide poisoning is a serious public health concern all over the world. Alternative therapies for organophosphorus are being explored, and this could be very useful especially in emergency situations of antidote shortages. This study therefore set out to determine effects chlorpheniramine on kidney liver function dichlorvos poisoning. Methodology: Chlorpheniramine (2mg/kg, 4mg/...

effects of four pesticides (imidacloprid, dichlorvos, pymetrozine and abamectin) were evaluated on life table parameters of orius albidipennis (reuter). pesticides were used at the concentrations recommended by the manufacturers. the bioassays were carried out using drum-cell method, in a growth chamber at 27 â± 1âºc, r.h. of 65 â± 5% and 16 h photo phase. the net reproductive rate (r0) value f...

Studies in mice and guinea pigs have shown that albumin is a new biomarker of organophosphorus toxicant (OP) and nerve agent exposure. Our goal was to determine whether OP-labeled albumin could be detected in the blood of humans exposed to OP. Blood from four OP-exposed patients was prepared for mass spectrometry analysis by digesting 0.010 ml of serum with pepsin and purifying the labeled albu...

The goal of this study was to develop a sensitive in vitro bioassay for quantification of the total esterase inhibiting potency of low concentrations of organophosphate and carbamate insecticides in relatively small rainwater samples. Purified acetylcholinesterase (AChE) from electric eel (Electrophorus electricus) and carboxylesterases from a homogenate of honeybee heads (Apis mellifera) were ...

Dichlorvos (dimethyl 2,2-dichlorovinyl phos­ phate) is a methylating compound 1 and it has been shown to methylate nucleic acid in vitro 2’ 3 and in bacteria3’ 4 as well as to yield 7-methylguanine in mice following i.p. injection and inhalation ex­ posure 4. In the present study two male R strain rats (240 and 260 g, 3 1/2 months old) were given 225 /<Ci of [14C-methyl]-dichlorvos (3.2 mCi/mmo...

A 25-year-old married primigravida was admitted to Pingjin Hospital after ingestion of dichlorvos, with suicidal intent. The initial serum dichlorvos level was 1.7 umol/L, with a reduction in cholinesterase activity of 29% in whole blood. Abdominal investigation revealed a soft abdomen with a pregnant uterus consistent with 9th week of gestation on echography and with a viable fetus. The patien...

Dichlorvos-impregnated resin strips (DDVP pest strips) are among the few organophosphate products still available for indoor residential use. The residential uses for most other organophosphate products, including most DDVP products, were canceled because they posed unreasonable risks to children. DDVP pest strips act by inhibiting acetylcholinesterase activity in the brain and nerves of insect...