Current knowledge on the pathogenesis of diastolic heart failure predominantly rests on case-control studies involving symptomatic patients with preserved ejection fraction and relying on invasive diagnostic procedures including endomyocardial biopsy. Our objective was to gain insight in serum and urinary biomarkers reflecting collagen turnover and associated with asymptomatic diastolic LV dysf...

OBJECTIVE To test the hypothesis that, when measured in the long axis, left ventricular systolic function is abnormal in patients with diastolic heart failure. DESIGN A case-control study. SETTING University teaching hospital (tertiary referral centre). PATIENTS 68 patients with heart failure, 29 with a left ventricular ejection fraction (LVEF) of > 0.45 and diastolic dysfunction (diastol...

BACKGROUND Gradual impairment of exercise tolerance is the commonest sign of heart failure (HF). Little is known as to which cardiac contributors of poor exercise capacity carry an independent prognostic information in HF. AIM We investigated the prognostic role of exercise echocardiography (ex-echo) in HF patients. METHODS We studied 85 consecutive, symptomatic HF patients (66 males, mean ...

abstract background prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia. materials and methods sixty-six patients with major thalassemia were studied in amir kabir hospital, arak, iran. serum ferritin levels were...

objectives: the prevalence of consanguineous marriage is about 30 % in iran and this can increase the probability of incidence of genetic impairments such as hearing impairments. hearing impairment in comparison with other hereditary disorders is the most incident. the purpose of this survey is to identify the prevalence of consanguinity among the parents of sensoryneural hearing impaired stude...

Impaired renal function with loss of nephron number in chronic renal disease (CKD) is associated with increased cardiovascular morbidity and mortality. However, the structural and functional cardiac response to early and mild reduction in renal mass is poorly defined. We hypothesized that mild renal impairment produced by unilateral nephrectomy (UNX) would result in early cardiac fibrosis and i...

OBJECTIVES To clarify the type of fetal growth impairment associated with increased blood pressure in adult life, and to establish whether this association is influenced by obesity and is mediated through impairment of insulin action. DESIGN Cross sectional survey with retrospective ascertainment of size at birth from obstetric archives. SUBJECTS 1333 men resident in Uppsala, Sweden, who to...

Introduction:Asthma is the most common chronic inflammatory condition affecting the lower airways among children. Asthma may influence right ventricular (RV) function and patients may develop right ventricular hypertrophy, pulmonary hypertension and cor pulmonale. The main objective of this study is to determine RV dysfunction in asymptomatic asthmatic children as detected by ti...