Amyloid is an eosinophilic substance which appears “apple-green birefringence” in Congo red stained tissue sections under polarized light. This standard histological analysis is supported with immunochemistry technic using specific antibodies directed against most of the common human amyloid proteins, and also amyloid proteins can be identified with characteristic fibrillar appearance by electr...

BACKGROUND The prognosis of monoclonal gammopathies with multiple myeloma and renal involvement is poor, and the indication for renal replacement therapy is controversial. Few studies address the value of renal histology for determining prognosis according to initial pathology findings. METHODS We studied the course of 118 patients with multiple myeloma according to renal biopsy lesions. The ...

In the last 10 years, the concept of biocompatibility as applied to haemodialysis membranes has gained a general clinical acceptance in light of the knowledge that the clinical expression of b2-microglobulin (b2m) amyloidosis found in long-term haemodialyzed patients was governed by the characteristics of dialysis membranes. Highly permeable and biocompatible synthetic membranes interfere with ...

term hemodialysis and it is characterized by the accumulation of β2-microglobulin in the osteoarticular structures. In 1984, Kuntz et al. (1) first described destructive spondyloarthropathy in ten patients who received longterm hemodialysis. The lesions in that study were radiographically characterized by severe narrowing of the intervertebral disk and erosions and cysts of the adjacent vertebr...

Introduction. Secondary renal amyloidosis due to tuberculosis is a debilitating disease with considerable mortality and morbidity due to renal failure and other manifestations of both amyloidosis and renal failure. Most patients with amyloidosis have been adequately treated with DOTS (Directly observed treatment, Short Course strategy). The aimof our study was to analyze the epidemiological and...

In the early 1900s, Alois Alzheimer diagnosed one of his patients with a devastating neurological impairment, and this form of dementia became known as Alzheimer's disease (AD). Much research over the past century has clearly established that numerous human diseases, ranging from AD and Parkinson's disease to dialysis-related amyloidosis, are best characterized by the abnormal aggregation of sp...

Pain is a major health problem in end-stage renal disease (ESRD) affecting half of the dialysis patients; most of them experience a moderate to severe degree of pain. Nevertheless, the impact of chronic pain and its consequences are often underestimated. Sources of pain related to the uremic environment are renal bone disease (osteitis fibrosa cystica, amyloidosis, osteomalacia), osteoarthritis...