OBJECTIVE Dynamically regulated expression of the gap junction protein connexin (Cx)43 plays pivotal roles in wound healing. Cx43 is normally downregulated and Cx26 upregulated in keratinocytes at the edge of the wound as they adopt a migratory phenotype. We have examined the dynamics of Cx expression during wound healing in diabetic rats, which is known to be slow. RESEARCH DESIGN AND METHOD...

wound site plays an essential role in wound healing as these can contribute directly to vasculogenesis.This process is dysregulated in diabetic wounds. It has been shown that injury-induced Hoxa3 expression is impaired in diabetic mice and this affects the recruitment of cells to the wound. Restoration of Hox transcription factor results in a decrease in inflammatory cell (CD45+) and an increas...

Background & Objective:  Wound dressing and healing in diabetic patients is encountered with many problems. This study aims to investigate the effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on the survival of random skin flap (RSF) on Streptozotocin-induced diabetic rats (STZ) using an optical microscope. Materials & Methods:  In this study, 60 male Albino Wistar rats were used...

Introduction: Wound cleansing remains a corner stone in the management of diabetic foot ulcer. Hydrogen Peroxide (H2O2) and Povidone Iodine are topical antimicrobial agents but known to be toxic to cells involved in the wound healing cascade. The biggest challenge for the physicians and nurses is searching for a safe, noncytotoxic and effective wound cleansing as Hypochlorous acid (HOCL). This ...

OBJECTIVE a network meta-analysis was performed to compare the strength and weakness of negative pressure wound therapy (NPWT) with ultrasound debridement (UD) as for diabetic foot ulcers (DFU). METHODS PubMed, Ovid EMBASE, Web of Science, Cochrane library databases, and Chinese Biomedical Literature Database were searched till February 2015. Clinical compared studies of negative pressure wou...

Background: The number of patients suffering from diabetic ulcers has been increased in recent years and the current therapies have faced failure. This study aimed to investigate the effects of Wharton’s jelly stem cells (WJMSCs) on the diabetic wound in an animal mode. Methods: During this laboratory experimental study carried out in Skin and Stem Cells Research Center from March 2021 to Nove...

BACKGROUND/AIMS Impaired wound healing is considered to be one of the most serious complications associated with diabetes as it significantly increases the susceptibility of patients to infection. Propolis is a natural bee product used extensively in foods and beverages that has significant benefits to human health. In particular, propolis has antioxidant, anti-inflammatory and analgesic effect...

Delayed wound healing is producing high economic burden on the society and is generally associated with Diabetes mellitus or related complications thus needs safe treatment like herbal formulation. „Amree Plus® (an anti-diabetic ayurvedic formulation)‟ was evaluated for wound healing potential in normal and diabetic rats. The effect of polyherbal formulation Amree plus ® on wound healing has be...

Diabetic mice are characterized by an altered expression pattern of VEGF, and impaired vasculogenesis during healing. We investigated the effects of porcine derived relaxin in diabetes-related wound healing defects in genetically diabetic mice. An incisional wound model was produced on the back of female diabetic C57BL/KsJ-m+/+Lept(db) (db+/db+) mice and their normal littermates (db+/+m). Anima...

UNLABELLED This study is designed to evaluate the effect of Equisetum arvense (EA) ointment on dermal diabetic wound healing in streptozotocin-induced diabetic rats. METHODS In this study, diabetes was induced via a single intraperitoneal injection of 65 mg/kg streptozotocin in 56 male Wistar rats. After anesthetization, a 15 mm x 15 mm wound for each rat was made by removing skin in a circle...