Diabetic retinopathy (DR) is the most common complication of diabetes and a major cause vision loss worldwide. The premature death microvascular mural cells represents both pathological hallmark vasodegeneration in DR basis for therapeutic intervention to halt progression sight-threatening stages. Recent studies suggest that retinal cells, classed as pericytes capillaries vascular smooth muscle...

Neurodegeneration is a central aspect of the early stages of diabetic retinopathy, the primary ocular complication associated with diabetes. While progress has been made to improve the vascular perturbations associated with diabetic retinopathy, there are still no treatment options to counteract the neuroretinal degeneration associated with diabetes. Our previous work suggested that the molecul...

Diabetic retinopathy (DR) is a serious microvascular complication of diabetes and a major cause of blindness in the developing world. Early diabetic retinopathy is characterized by a loss of pericytes and vascular endothelial cells, a breakdown of the blood-retinal barrier, vascular dysfunction and vascular-neuroinflammation. However, optimal treatment options and related mechanisms are still u...

RATIONALE Vascular calcification is a serious cardiovascular complication that contributes to the increased morbidity and mortality of patients with diabetes mellitus. Hyperglycemia, a hallmark of diabetes mellitus, is associated with increased vascular calcification and increased modification of proteins by O-linked N-acetylglucosamine (O-GlcNAcylation). OBJECTIVE We sought to determine the ...

diabetic retinopathy is a common complication of type ii diabetes mellitus and carries with it the threat of blindness. accurate information regarding the incidence of diabetic retinopathy and associated risk factors is important in the prevention of its development and of the visual impairment caused by this complication. this study was designed to determine the prevalence of diabetic retinopa...

objective(s) diabetes related dysfunction of resistance vessels is associated with vascular occlusive diseases. vasorelaxant agents may have a role in control of diabetic cardiovascular complications. gamma aminobutyric acid (gaba) has demonstrated to cause vasorelaxation. the present study was designed to determine i) the vasorelaxatory effect of gaba on diabetic vessels and ii) the role of en...

Two West Indian men with no previous history of diabetes mellitus developed hyperosmolar non-ketotic diabetic coma. Intra-abdominal catastrophes secondary to mesenteric thrombosis played a major part in the death of these patients, in both of whom control of the hyperosmolar state had been achieved. Both patients had evidence of infarction of intestine at necropsy. Vascular thromboses are a maj...

Diabetic complications are generally classified into macrovascular and microvascular conditions. Depending on the location of atherosclerotic lesion, disease (coronary artery disease, cerebrovascular peripheral vascular disease) may occur. The prevalence diabetes its complication is increasing all over world, particularly in developing countries. It has emerged as a major public health problem ...

Abstract Background Diabetic encephalopathy is a severe diabetes complication with cognitive dysfunction and neuropsychiatric disability. The mechanisms underlying diabetic believed to be relevant oxidative stress, vascular amylin deposition, immune receptors, inflammation, etc. This study wanted evaluate the ability of curcumin its analog A13 alleviate stress inflammation in diabetes-induced d...