BACKGROUND Type 2 diabetes is associated with greater relative risk of cardiovascular diseases in women than in men, which is not well understood. Consequently, we have investigated if male and female displayed differences in cardiac function, energy metabolism, and endothelial function which could contribute to increased cardiovascular complications in type 2 diabetic female. METHODS Male an...

BACKGROUND Nitric oxide (NO) has been noted to produce ischemic preconditioning (IPC)-mediated cardioprotection. Caveolin is a negative regulator of NO, which inhibits endothelial nitric oxide synthase (eNOS) by making caveolin-eNOS complex. The expression of caveolin is increased during diabetes mellitus (DM). The present study was designed to investigate the involvement of caveolin in attenua...

The Spontaneously Diabetic Torii (SDT) rat, a nonobese type 2 diabetes model, develops severe diabetic retinopathy as result of chronic severe hyperglycemia. Although existing diabetes animal models also develop ocular complications, severe retinal lesions frequently observed in human diabetes patients such as preretinal neovascularization or retinal detachment are not found. Distinctive featur...

Diabetic neuropathy is a common complication of diabetes. It occurs in approximately 10-20% of patients with diabetes, or roughly 40-50% patients with diabetic neuropathy. However, the pathogenesis of diabetic neuropathic pain is still largely unknown. Several animal models have been used to study the underlying mechanisms for this complication. Some commonly used animal models include streptoz...

This study investigated the effect of combined seeds Sesemum indicum (SI) and Moringa oleifera (MO) on liver function markers in alloxan-induced diabetic albino rats. 54 rats were divided into 9 groups 6 animals each. Group 1 served as normal control received standard feed diet, 2 (Diabetic control) intraperitoneal injection 140mg/kg Alloxan, 3 (Positive 5mg/kg glibenclamide, 4; fed diet contai...

The study was undertaken to evaluate the therapeutic efficacy of water extract of Rosmarinus officinalis L. (rosemary) in St reptozotocin (STZ) induced diabetic rats. The effect of extract on serum card iac enzymes in STZ induced diabetic rat models and normal control rats were determined. Extract was administered orally, to STZ-induced diabetic rats, at a dose of 200 mg / kg body weight/day fo...

Diabetic retinopathy, a retinal vascular disease, is inhibited in animals treated with aminoguanidine, an inhibitor of inducible nitric-oxide synthase. This treatment also reduces retinal protein nitration, which is greater in diabetic rat retina than nondiabetic retina. As an approach to understanding the molecular mechanisms of diabetic retinopathy, we sought the identity of nitrotyrosine-con...

Background: Gestational diabetes mellitus affects 3-5% of all human pregnancy.Studies reported the neurotoxic effect of gestational diabetes on cerebellarand spinal cord in rat offspring. This study was conducted to determine the effect of gestational diabetes on astrocyte density in the cerebellum of rat offspring. Materials and Methods: In this experimental study, 30 Wistar rats dams were ran...

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