نتایج جستجو برای: dgcr8

تعداد نتایج: 347  

Journal: :Nature Structural & Molecular Biology 2012

2014

Expatriation is one of the key staffing policies used by MNCs to fill managerial positions in their foreign operations. But, many times it has been associated with the phenomenon of expatriate failure resulting from the inability of the expatriated manager and his (her) family to adjust to the host country environment. Purpose of this paper was so to provide an overview on the international lit...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Laurie R Earls R Gaines Fricke Jing Yu Raymond B Berry Lisa T Baldwin Stanislav S Zakharenko

The 22q11 deletion syndrome (22q11DS) is characterized by multiple physical and psychiatric abnormalities and is caused by the hemizygous deletion of a 1.5-3 Mb region of chromosome 22. It constitutes one of the strongest known genetic risks for schizophrenia; schizophrenia arises in as many as 30% of patients with 22q11DS during adolescence or early adulthood. A mouse model of 22q11DS displays...

2014
Céline Zimmermann Yannick Romero Maria Warnefors Adem Bilican Christelle Borel Lee B. Smith Noora Kotaja Henrik Kaessmann Serge Nef Helen White-Cooper

Small non-coding RNAs act as critical regulators of gene expression and are essential for male germ cell development and spermatogenesis. Previously, we showed that germ cell-specific inactivation of Dicer1, an endonuclease essential for the biogenesis of micro-RNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs), led to complete male infertility due to alterations in meiotic progr...

2016
M Toyoshima W Akamatsu Y Okada T Ohnishi S Balan Y Hisano Y Iwayama T Toyota T Matsumoto N Itasaka S Sugiyama M Tanaka M Yano B Dean H Okano T Yoshikawa

Given the complexity and heterogeneity of the genomic architecture underlying schizophrenia, molecular analyses of these patients with defined and large effect-size genomic defects could provide valuable clues. We established human-induced pluripotent stem cells from two schizophrenia patients with the 22q11.2 deletion (two cell lines from each subject, total of four cell lines) and three contr...

2016
Luqing Zhao Yitao Mao Yuelong Zhao Yanong He

DDX3X, located on the X-chromosome, belongs to the DEAD-box RNA helicase family and acts as a key RNA-binding protein to exert its regulatory functions in various biological processes. In this paper, knock-down the expression of DDX3X can affect a subset of miRNA expression levels, especially for miR-1, miR-141, miR-145, miR-19b, miR-20a and miR-34a. Through adopting the immunoprecipitation (IP...

1998
E. Fjeld L. A. Vøllestad

Ž . Ž Embryos of grayling Thymallus thymallus were exposed to different concentrations of methylmercury 0.16, 0.8, yl. 4.0 and 20 mg Hg l during the first 10 days of development. The exposure resulted in body concentrations in the newly hatched fry of 0.09, 0.27, 0.63 and 3.80 mg Hg gy1 wet wt., respectively. A control group had a body concentration of 0.01 mg Hg gy1. Morphological disturbances...

2013
Andreas J. Forstner Franziska Degenhardt Gerhard Schratt Markus M. Nöthen

The 22q11.2 deletion is the strongest known genetic risk factor for schizophrenia. Research has implicated microRNA-mediated dysregulation in 22q11.2 deletion syndrome (22q11.2DS) schizophrenia-risk. Primary candidate genes are DGCR8 (DiGeorge syndrome critical region gene 8), which encodes a component of the microprocessor complex essential for microRNA biogenesis, and MIR185, which encodes mi...

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