BACKGROUND Many studies have investigated the relationship between blood levels of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEA-S), cortisol, progesterone, and testosterone and the onset, prognosis, symptom severity, and treatment response of schizophrenia. In the present study, we assessed potential differences in blood levels of neurosteroids between drug-naïve first-episode pati...

Individuals chronically exposed to low levels of organophosphate insecticides may present with subtle impairments in cognition. In addition, low level diisopropylflurophosphate (DFP) exposure (0.25 mg/kg per day for 2 weeks) in rats resulted in protracted working memory impairment [29]. The current studies attempt to show a temporal relationship between the DFP-induced impairment in performance...

Recently, we developed a series of cytotoxic peptide conjugates containing 14-O-glutaryl esters of doxorubicin (DOX) or 2-pyrrolino-DOX (AN-201). Serum carboxylesterase enzymes (CE) can partially hydrolyze these conjugates in the circulation, releasing the cytotoxic radical, before the targeting is complete. CE activity in serum of nude mice is about 10 times higher than in human serum. Thus, w...

Methods Among the first 1135 TM patients enrolled in the MIOT (Myocardial Iron Overload in Thalassemia) network, 392 patients performed a MR follow up study at 18 ± 3 months according to the protocol. We evaluated prospectively the 193 TM patients who had been received one chelator alone between the 2 MR scans. We identified 3 groups of patients: 80 treated with DFX, 39 treated with DFP and 74 ...

Five sequential steps interspaced between the antigen activation of human lung fragments sensitized with IgE and the release of the chemical mediators, histamine and slow-reacting substance of anaphylaxis (SRS-A), have been delineated. The experimental design that permits this analysis is based upon the capacity to maintain the serine esterase essential to mediator release in its diisopropylpho...

In many engineering applications, it is often the case that observations are only available in interval form. this note, by using expectation-maximization (EM) algorithm, parameter estimation of Weibull distribution with interval-censored data considered. The estimates obtained EM algorithm compared those conventional Newton-type methods, including Davidon–Fletcher–Powell (DFP) and Berndt–Hall–...

The high-speed three-dimensional movement dynamic friction polishing (3DM-DFP) has been recognized as an efficient approach for ultra-smoothing single crystal diamond (SCD) surface. Continuing from the previous works focusing on subsurface cleavage of after 3DM-DFP, process optimization and surface reaction evolution mechanism a fundamental building block is investigated, first time, comprehens...

Among the various stages of fruit harvest (35, 40, 45 DFP under open field (E1); and 45, 50, 55 protected (E2) environments, in combination with post-harvest ripening (PHR) periods (0, 10, 20 30-days);treatment F2P4 (40 DFP+30-days PHR), followed by F3P3 (45 DFP+20-days PHR) field, whereas, treatment C2P4 (50 C3P3 (55 environment, were superior optimizing both seed yield quality two cucumber va...

Digital fringe projection (DFP) profilometry has been widely used to generate threedimensional (3D) surface information. In this work, a novel 3D shape measurement system based on DFP technique is proposed for accurate and quick thin film/rivulet flow measurement. The key concept of the technique is making use of digital image correlation (DIC) algorithm to direct calculate the projected grid p...

Purpose. Docetaxel/5-FU/CDDP (DFP) therapy is a useful treatment for advanced esophageal cancer. However, adverse reactions such as chemotherapy-induced nausea and vomiting (CINV) interfere often with continuation of the chemotherapy. We investigated the efficacy of rikkunshito (TJ-43) on CINV. Methods. Nineteen patients who were going to undergo DFP therapy were enrolled. They were assigned to...