Earlier observations indicated that volume exclusion by admixed non-hemoglobin macromolecules lowered the polymer solubility ("Csat") of deoxyhemoglobin (Hb) S, presumably by increasing its activity. In view of the potential usefulness of these observations for in vitro studies of sickling-related polymerization, we examined the ultrastructure, solubility behavior, and phase distributions of de...

A total arrest of cell membrane movement occurred after incubation for 2 h of cultured fibroblasts with the polycation DEAE-dextran. The immobilized cells resumed normal membrane undulations after exposure for 5 min to the polyanion dextran-sulphate. The influence of DEAE-dextran on the electrophoretic mobility, which was seen after 10 min of incubation was also erased by a subsequent incubatio...

Hypoxic pulmonary vasoconstriction (HPV) is a regulatory mechanism by which blood is diverted from poorly ventilated to better ventilated areas of the lung. The aim of the present study was to assess the extent to which hypertonic saline dextran and dextran solutions modify the magnitude of HPV during isovolumic haemodilution in intact acutely instrumented piglets. Eighteen large white piglets ...

Dextran a bacterial exopolysaccharide and a polymer of glucose is produced by different microorganisms like Leuconostoc mesenteroides, Lactobacillus spp, Streptococcus mutans, Weissella confusa etc. It has a wide range of applications in the food, pharmaceutical and other industries. Dextran and its derivatives like iron dextran, clinical dextran, food grade dextran are rapidly emerging as new ...

this paper provides an overview of how the surface properties of ferromagnetic nanoparticles dispersed in fluids is modified by natural and biocompatible polymers. among common magnetic nanoparticles, magnetite (fe3o4) and maghemite (g-fe203) are popular candidates because of their biocompatibility. natural polymeric coating materials are the most commonly used biocompatible magnetic nanopartic...

OBJECTIVE The objective of this study was to evaluate the effect of the labeling of umbilical cord vein derived mesenchymal stem cells with superparamagnetic iron oxide nanoparticles coated with dextran and complexed to a non-viral transfector agent transfector poly-L-lysine. METHODS The labeling of mesenchymal stem cells was performed using the superparamagnetic iron oxide nanoparticles/dext...

Nowadays, a great demand for the development of novel drug delivery systems with high potential bench-to-market transition attracts scientific attention toward materials that are already approved biomedical use. Here, controlled fabrication hybrid organic inorganic mesoporous crystals is realized in physiologically relevant conditions by co-synthesis vaterite CaCO3 presence dextran (DEX) or its...

One of the most extensively utilized rapid characterization, release and stability testing methods therapeutic proteins in biopharmaceutical field today is capillary SDS gel electrophoresis using borate cross-linked high molecular weight dextran. In spite its widespread use, however, composition dependent separation characteristics this very unique sieving matrix has not been investigated yet. ...