glutaric acidemia, type i (ga i), was first described in 1975. the disease is caused by a genetic deficiency of the enzyme, glutaryl-coa dehydrogenase (gcd), which leads to the buildup of glutaric acid in the tissues and its excretion in the urine of affected patients. gcd is involved in the catabolism of the amino acids, lysine, hydroxylysine, and tryptophan. over 200 cases of ga i have been r...

background and objectives: contamination of cell lines and biological products is one of the major problems of cell culture techniques. rapid detection of mycoplasma contamination in cell culture is an important part of quality control standards in related laboratories. the aim of this study was to evaluate the efficacy of pcr in detection of myroplasma as contaminants in cell cultures and othe...

introduction: this paper addresses a method for automatic detection of blood vessels in color fundus images which utilizes two main tools: image partitioning and local radon transform. material and methods: the input images are firstly divided into overlapping windows and then the radon transform is applied to each. the maximum of the radon transform in each window corresponds to the probable a...

cryptococcosis has become the fourth leading life-threatening opportunistic infection in patients with aids, but also occurs in non-aids patients. in view of the increasing numbers of infection during last decade in iran, use of rapid, sensitive and specific test for diagnosis of cryptococcal disease has become important than ever. we aimed to produce the reagents for latex cryptococcal antigen...

a sensitive procedure for determining total vitamin c (ascorbic acid + dehydrate ascorbic acid) in a blood drop from a finger prick, before and after the adminis- tration of a vitamin c tablet is described. analysis was carried out by high per- formance liquid  chromatography with  electrochemical detection (hplc/ec). measurements were taken one hour, two hours and six hours after the administr...

cancer, with a high rate of mortalities worldwide, pose a major threat to human health. although family history accounts for at least 5-10% of all cancers, it is conferred to be as a significant risk of developing cancer. recently, application of high speed and low cost high-throughput nucleotide sequencing technologies has provided an opportunity to assess cancer risk in at risk healthy indivi...

breast cancer is the most important and prevalent cancer in women that can be managed if detected in the early stages. recently, there has been much focus on the use of epigenetic changes such as dna methylation in early detection of cancer. as recent research has put forth dok7 cpg island methylation as an epimarker, in the present study, using a quantification method, a cohort of iranian spor...