OBJECTIVES Oral cancer is the sixth most common malignancy worldwide. Cancer development and progression requires inactivation of tumour suppressor genes and activation of proto-oncogenes. Expression of these genes is in part dependant on RNA and microRNA based mechanisms. MicroRNAs are essential regulators of diverse cellular processes including proliferation, differentiation, apoptosis, survi...

Diurnal variations in nitrate reductase (NR) activity and nitrogen metabolites were examined in wild-type Nicotiana plumbaginifolia and transformants with various degrees of NR deregulation. In the C1 line, NR was only deregulated at the transcriptional level by placing the NR gene under the control of the cauliflower mosaic virus 35S RNA promoter. In the Del8 and S521D lines, NR was additional...

Emerging evidence assigns to epigenetic mechanisms heritable differences in gene function that come into being during cell development or via the effect of environmental factors. Epigenetic deregulation is strongly involved in the development of hepatocellular carcinoma (HCC). It includes changes in methionine metabolism, promoter hypermethylation, or increased proteasomal degradation of oncosu...

In 1996, free market Republicans and budget-cutting Democrats offered farmers a deal: accept a cut in farm subsidies and, in return, the government would promote exports in new trade deals with Latin America and in the World Trade Organization (WTO) and eliminate restrictions on planting decisions. In economic terms, farmers were asked to take on risks heretofore assumed by the government in ex...

Deregulation of power system industry is a very large complex exercise based on respective national energy strategies and policies. A lot of matters and knowledge need to be studied before the idea of deregulation can be implemented. Theoretically, it is said that deregulation can make a large impact to increase efficiency and encourage the competitiveness among related parties. However, to imp...

THE PURPOSE of this paper is to bring to the attention of a larger, nonspecialized audience a possible change in policy that may have wide and costly ramifications: deregulation of natural gas prices. There is some value in making even rough "guesstimates" of the economic implications of price deregulation because of the general bias that both economists and businessmen have in favor of deregul...