The present communication reports some medicinal plants which are used as Central Nervous System sedative agent in the traditional system of medicine.

A patient with marked manifestations of myotonic dystrophy presented for surgical correction of cataracts. Propofol was used as part of the anaesthetic technique. The patient demonstrated marked sensitivity to its central depressant effects.

1 Morphine reduces the amplitude of the contractions induced by electrical stimulation, in the myenteric plexus-longitudinal muscle preparation of guinea-pig ileum. Dopamine and apomorphine have the same effect but at much higher concentrations. 2 Dopamine, at concentrations lower than those which would normally be inhibitory, partially reverses the depressant effect of morphine. 3 Pre-treatmen...

Administration of N-methyl-D-aspartate receptors (NMDAR) antagonists initiates a rapid anti-depressant response requiring mammalian Target of Rapamycin Complex 1 (mTORC1) kinase; however the molecular mechanism is unknown. We have determined that upon NMDAR blockade, dendritic γ-amino-butyric acid B receptors (GABABR) facilitate dendritic calcium entry. The GABABR-mediated increase in calcium s...

Pharmacological studies were undertaken to clarify the profile of cis-2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl) butyl) hexahydro-1H-isoindole-1,3-(2H)-dione hydrochloride (SM-9018), a new neuroleptic drug. SM-9018 had very high binding affinities for both 5-hydroxytryptamine2 (5-HT2) and dopamine2 (D2) receptors, unlike many other neuroleptics. SM-9018 also strongly inhibited 5-HT2 recep...

The effect of propranolol on the electric stimulation of rat isolated diaphragm shOwed the depression of its isometric force of contraction. This depressant effect of propranolol on the rat isolated diaphragm was produced in doses much higher than the doses required for the beta adrenergic receptor blocking activity. Isoprenaline showed no effect on the rat isolated diaphragm and it did not ant...

Objective: The objective was to evaluate depressant effects on central nervous system (CNS) and behavioral of ethanol extract clitoria annua find the phytochemical responsible for these activities with possible mode action. Materials & Method: activity C. evaluated by classical models depression as Rota rod method, Actophotometer test, tail suspension, thiopental sodium induced sleeping tim...

AIM To investigate methanol extracts of various parts of Rubus fruticosus L. (Rosaceae) for various neuropharmacological activities, such as anxiolytic, muscle relaxant, antidepressant, and sedative activities. MATERIALS AND METHODS The extracts were administered to albino mice orally at doses of 100, 300, and 500 mg/kg. The antidepressant activity was determined by using the forced swimming ...