Recent advances in the understanding of molecular underpinnings metastatic breast cancer have led to identification novel therapeutic targets. The latest update NCCN Guidelines for Breast Cancer reflects a rapidly evolving treatment landscape, highlighting growing importance combination therapies and personalized medicine managing estrogen-receptor (ER)–positive, HER2-positive, triple-negative ...

A number of proteins are (partially) unstructured at physiological conditions and assume a well-defined three-dimensional structure only upon binding to another protein or macromolecular complex. Numerous examples have been found especially among proteins involved in regulatory functions in eukaryotic cells. Recent computer simulations by Verkhivker et al. have yielded an atomic detail picture ...

Background: Novel roles for the interaction of cardiotonic steroids to Na+/K+-ATPase have been established in recent years. The aim of the present study was to investigate the intracellular signaling events downstream the action of ouabain on Na+/K+-ATPase in Sertoli cell obtained from immature rats. Treatment of Sertoli cells with ouabain (1 μM) induced a rapid and transient increase in the ex...

Abstract Myeloid-derived suppressor cell (MDSC) comprises a heterogeneous population of immature myeloid cells featured by potent immunosuppression. We have uncovered significant role hepatoma-intrinsic cyclin-dependent-kinase 20 (CDK20), or cell-cycle-related-kinase (CCRK) in promoting tumor progression and immunotherapy resistance hepatocellular carcinoma (HCC). As emerging evidence has highl...

Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII. We show that DLG and CaMKII colocalize at synapses and exist in the same protein complex. Constitutively activated CaMKII phenocopied structural abnormalities of dlg mutant synapses and dramatically increased extrajunctional DLG. Decreased CaMKII ...