To test the ability of regenerated endothelium to evoke endothelium-dependent relaxations, male Yorkshire pigs underwent balloon endothelial denudation of the proximal left anterior descending coronary artery. Endothelium-dependent responses were examined in vitro, in rings of coronary segments taken from the denuded area or from the proximal left circumflex coronary artery. The experiments wer...

High rates of erosion (1-15 mm/yr) of fluvial strata have persisted over intervals of 0.2-1.5 m.y. and across areas of 60-2000 km 2 in the Cenozoic foreland basin of northern Pakistan. These rates occur in areas associated with thrust shortening, and they indicate that erosion nearly kept pace with the rates of latest Miocene to Pleistocene uplift. Such high rates of erosion are predicted to pr...