The Spindle Assembly Checkpoint (SAC) delays the onset of anaphase until every chromosome is properly bioriented at the spindle equator. Mutations in SAC genes have been found in tumors and compromised SAC function can increase the incidence of some carcinomas in mice, providing further links between cancer etiology, chromosome segregation defects and aneuploidy. Here we review recent developme...

cAMP is a critical second messenger mediating activity-dependent neuronal survival and neurite growth. We investigated the expression and function of the soluble adenylyl cyclase (sAC, ADCY10) in CNS retinal ganglion cells (RGCs). We found sAC protein expressed in multiple RGC compartments including the nucleus, cytoplasm and axons. sAC activation increased cAMP above the level seen with transm...

Background: To evaluate the role of 3D, 4D and color Doppler ultrasound (US) in the assessment of early human development. Materials and Methods: 380 women with uncomplicated early pregnancy between 5 and 14 weeks were evaluated by 3D, 4D and color Doppler US. Results: Regression analysis revealed exponential rise of the gestational sac volume with gestational age throughout the first trimester...

Nonlinearity, 0-1 balancedness and strict avalanche criterion (SAC) are important criteria for cryptographic functions. Bent functions have maximum nonlinearity and satisfy SAC however they are not 01 balanced and hence cannot be directly used in many cryptosystems where 0-1 balancedness is needed. In this paper we construct (i) 0-1 balanced boolean functions on V2k+1 (k ≥ 1) having nonlinearit...

experimental determination of solubility and ternary phase diagram of chiral compound are of tedious and time consuming tasks, and in many cases, there is not enough experimental data for different enantiomeric compositions to access the experimental ternary phase diagram. using thermodynamic models with predictive capability, having less dependency on experimental data, affords a great advanta...

Multiple calcified hyperplastic dental follicles (MCHDF) are an extremely rare condition which has been categorized as a separate pathological entity very recently. It was initially described by Sandler et al. Gardner and Radden proposed this as a separate pathological entity. This disease is characterized by multiple unerupted teeth with abundant calcifications and rests of odontogenic epithel...

We report our experience with a case of presumptive cesarean scar pregnancy, based on detection of a gestational sac (GS) in early pregnancy at the site of a previous cesarean scar. The GS grew into the uterine cavity as the pregnancy progressed, showing an ultrasound image similar to that of a normal pregnancy. Thus, the pregnancy continued, resulting in a viable birth at 28 weeks of gestation...

S = support of heart afforded by the pericardium T = tone of muscle. The support of the pericardium is due to the negative pressure in the pericardial cavity which I have shown is present in health. This negative pressure causes a suction action which keeps the pericardium right up against the heart save for the thin layer of pericardial fluid so necessary for lubrication. F varies directly wit...

The objective of this prospective follow-up study was to evaluate the potential utility of three-dimensional (3D) ultrasound to differentiate intrauterine from extrauterine gestations. Fifty-four pregnancies with a gestational age <10 weeks and with an intrauterine gestational sac <5 mm in diameter formed the study group. The configuration of the endometrium in the frontal plane of the uterus w...