Neuromyelitis optica or Devic`s disease is an inflammatory disimmune-neurodegenerative characterized by a progressive course, predominantly affecting the optic nerves and spinal cord, with relatively intact brain structures. The differential diagnosis of neuromyelitis multiple sclerosis based on identification typical clinical tomographic picture presence high level antibodies to aquaporin 4 in...

polyomaviruses may cause human disease, particularly in immunocompromised hosts. jcv, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (pml), which occurs mostly in immunocompromised patients. progressive multifocal leukoencephalopathy (pml) is a progressive demyelinating disorder of the central nervous sy...

Infection of various cells with Theiler's murine encephalomyelitis virus (TMEV) activates the TLR- and melanoma differentiation-associated gene 5 (MDA5)-dependent pathways, resulting in the production of IL-1β via the activation of caspase-1 upon assembly of the node-like receptor protein 3 (NLRP3) inflammasome. The role of IL-1β in the pathogenesis of TMEV-induced demyelinating disease was pre...

A 57-year-old man presented with a 4-week history of fever, visual loss, and progressive ataxic gait. He worked as a truck driver and had been in contact with raw sheepskin a few months prior. Neurologic examination showed drowsiness, pseudobulbar syndrome, hyperreflexia, ataxia, and optic disc edema. He had a lymphocytic pleocytosis and diffuse hyperintense white matter lesions on brain MRI (f...