objective(s):the aim of this study was to prepare electrospun nanofibers of celecoxib using combination of time-dependent polymers with pectin to achieve a colon-specific drug delivery system for celecoxib. materials and methods:formulations were produced based on two multilevel 22 full factorial designs. the independent variables were the ratio of drug:time-dependent polymer (x1) and the amoun...

introduction: the risk of morbidity and mortality increases in neonates admitted to the neonatal intensive care units (nicus). various factors contribute to the prognosis of these newborns. in the current study, we aimed to investigate the role of mode of delivery on short-term neonatal outcomes. methods: this retrospective study was conducted on 215 neonates admitted to the nicu of shohada-e-t...

pain management is crucially important in the postoperative period as it increases patient comfort and satisfaction. the primary outcome of present study was to evaluate the effect of sufentanil added to hyperbaric bupivacaine solution 0.25% in transversus abdominis plane (tap) block, on postoperative analgesic consumption. fifty asa physical status i–ii term primiparous single-tone pregnant wo...

this study was designed to assess the frequency of exclusive breastfeeding in two health centers of shahid beheshti university of medical sciences in khak sefid, tehran, iran. a total of 175 mothers, referred for the third dose of their infants' dpt vaccination program participated in the study by completing a questionnaire regarding characteristics of their pregnancy, delivery and exclusive br...

the nasal cavity possesses many advantages as a site for drug delivery, such as, ease of administration, applicability for long term treatments and a large surface area for absorption. one important limiting factor for nasal drug delivery is the limited time available for absorption within the nasal cavity due to mucociliary clearance. several drug delivery systems including different kinds of ...

objective(s): nanoparticles (nps) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. the main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. methods: in this study, mesalamine loaded chitosan nanoparticles were pr...

nowadays apphcanon of nanotubes in biology and medicinal science is more investigated. nanotubes can passthroueh cell walls and transport and release drugs in special tissues. the purpose of this paper is to investigatethe interaction of a nanotube having hydroxyl functional groups (oh) with an anticancer agent. in this worktransporting of an anticancer drug named 2-(2-amino 6,7-dimethyl pterid...

carvacrol is one of the main components of the eo of some labiatae (laminaceae) members like oregano, thyme and savory. carvacrol has a lot of health benefits for example, antibacterial, and antioxidant activity.we synthesized some silicon derivatives of carvacrol, and characterized them by standard methods. then the monomer of dimethylvinylsilyl carvacrol was synthesized. copolymer of this mon...

objective(s): the introduction of nucleic acids into cells for therapeutic objectives is significantly hindered by the size and charge of these molecules and therefore requires efficient vectors that assist cellular uptake. for several years great efforts have been devoted to the study of development of recombinant vectors based on biological domains with potential applications in gene therapy....

abstract among synthetic carriers, dendrimers with the more flexible structure have attracted a great deal of researchers' attention in the field of gene delivery. followed by the promising results upon hydrophobic modification on polymeric structures in our laboratory, alkylcarboxylated poly (propylenimine)-based carriers were synthesized by nucleophilic substitution of amines with alkyl moiet...