Anna Nagurney Department of Finance and Operations Management Isenberg School of Management University of Massachusetts Amherst, Massachusetts 01003 Qiang Qiang Management Division Pennsylvania State University Graduate School of Professional Studies Malvern, Pennsylvania 19355 Ladimer S. Nagurney Department of Electrical and Computer Engineering University of Hartford West Hartford, Connecticu...

Creation of foam structures from hydrolytically degradable poly(ε-caprolactone) (PCL) is a current task in biomaterial research. One example are degradable scaffolds. The thermodynamic and kinetic conditions in a supercritical CO2 (scCO2) supported foaming process of PCL can influence the resulting morphology of the foam. PCL-foaming with scCO2 was systematically investigated in the pressure ra...

Many carbohydrates pose advantages for tissue engineering applications due to their hydrophilicity, degradability, and availability of chemical groups for modification. For example, carboxymethylcellulose (CMC) is a water-soluble cellulose derivative that is degradable by cellulase. Though this enzyme is not synthesized by mammalian cells, cellulase and the fragments derived from CMC degradatio...

Bone is the second most widely transplanted tissue after blood. Synthetic alternatives are needed that can reduce the need for transplants and regenerate bone by acting as active temporary templates for bone growth. Bioactive glasses are one of the most promising bone replacement/regeneration materials because they bond to existing bone, are degradable and stimulate new bone growth by the actio...

Current strategies to improve wound healing are often created from multiple components that may include a scaffold, cells, and bioactive cues. Acellular natural hydrogels are an attractive approach since the material's intrinsic biological activity can be paired with mechanical properties similar to soft tissue to induce a host's response toward healing. In this report, a systematic evaluation ...

objective(s):various methods for repairing bone defects are presented. cell therapy is one of these methods. bone marrow stromal cells (bmscs) seem to be suitable for this purpose. on the other hand, lots of biomaterials are used to improve and repair the defect in the body, so in this study we tried to produce a similar structure to the bone by the chitosan and hydroxyapatite. materials and me...

Multivinyl monomers that react to form highly crosslinked, biodegradable networks are being developed as scaffolds for tissue engineering and vehicles for drug delivery; however, this work demonstrates their usefulness in characterizing better the complexities of the kinetics and structural evolution during crosslinking photopolymerization. The molecular weight distributions (MWDs) of the degra...

Semi-synthetic, proteolytically degradable polymer hydrogels have proven effective as scaffolds to augment bone and skin regeneration in animals. However, high costs due to expensive peptide building blocks pose a significant hurdle towards broad clinical usage of these materials. Here we demonstrate that tri-amino acid peptides bearing lysine (or arginine), flanked by two cysteine residues for...