The human immunodeficiency viruses (HIV -1 and HIV -2), the etiological agents of the acquired immune deficiency syndrome (AIDS), beIong to the lentivirus subfamily of the Retroviridae famiIy. Sequence ana1ysis of viral DNA indicates a separate ancestral lineage for HIV 1 and HIV -2. PhyIogenetic anaIysis of diverse geographical isolates has shown HIV-l to cluster into two distinct major groups...

conclusions health care providers need to pay special attention to sexual transmission of hcv among hiv-infected individuals, and should recommend control/preventive measures for hcv sexual transmission. results age of the index samples was 38.71 ± 7 years, and 33.2 ± 6.3 for their main heterosexual partners; the mean duration of sexual relationship for couples was 11.9 (median = 8.5) years. mu...

Under nutrition and human immune deficiency virus/HIV have a vicious cycle. This study aimed to assess the pooled prevalence of under determinants among adults receiving antiretroviral therapy in Ethiopia. Google scholar, PubMed, Cochrane library web science data bases were searched. Studies assessed using risk bias assessment tool. The heterogeneity was I2 test statistics. Data random effect m...

Introduction: The human immunodeficiency virus (HIV) is a threat to global health and the need for finding new methods of antivirus research, in particular against HIV has increased in recent years. In this study, we investigated the ability of the cold atmospheric pressure plasma jet (CAPPJ) using helium to inhibit the replication of HIV virions. Methods: Single cycle replicable HIV (SCR-HIV) ...

Background.  Seronegative human immunodeficiency virus (HIV) infections are exceedingly rare but might inform HIV-host physiology. Methods.  We investigate the cause and consequences of a patient infected with HIV who did not mount a humoral response to HIV for 4 years. Results.  The patient was confirmed HIV-uninfected by nucleic acid testing 4 months before rapidly progressing to acquired imm...

BACKGROUND Factors that influence shedding of HIV-1 infected cells in cervical and vaginal secretions may be important determinants of sexual and vertical transmission of the virus. We investigated whether hormonal contraceptive use, vitamin A deficiency, and other variables were risk factors for cervical and vaginal shedding of HIV-infected cells. METHODS Between December, 1994, and April, 1...

background drug design against human immunodeficiency virus type 1 (hiv-1) integrase through its mechanistic study is of great interest in the area in biological research. the main obstacle in this area is the absence of the full-length crystal structure for hiv-1 integrase to be used as a model. a complete structure, similar to hiv-1 of a prototype foamy virus integrase in complex with dna, in...

The importance of zinc in normal immune function and of its deficiency in immune dysfunction has led to increased interest in its role in nutrition and immunity in human immunodeficiency virus type 1 (HIV) infection. Zinc deficiency produces reversible immune dysfunction, particularly of Tlymphocyte cell-mediated immunity. In developing countries where zinc deficiency is prevalent, zinc supplem...

conclusions the majority of hiv-infected persons in the city of kashan were also hcv positive. genotype 1 was the predominant type, alongside subtype a. considering the high prevalence of hcv among the hiv-infected persons, as well as the impact of occupation, education, illicit drug use, and imprisonment on the incidence of both infections, health policy makers must introduce health programs a...

HTLV-1 and HIV-1 are two major causes for severe T-cell leukemia disease and acquired immune deficiency syndrome (AIDS). HTLV-1 protease, a member of aspartic acid protease family, plays important roles in maturation during virus replication cycle. The impairment of these proteases results in uninfectious HTLV-1virions.Similar to HIV-1protease deliberate mutations that confer drug resistance on...