haematologica | 2009; 94(10) | 1435 | The standard phase III trial These trials typically randomize approximately 400 patients between two therapies. This relatively large number is required to detect relatively small improvements with a false positive rate less than 5% (p<0.05) and a false negative rate less than 20% (80% power). For example, the trials in references 1-3 targeted increases in ...

Within the past decades, major advances in therapy for chronic myelocytic leukemia, including allogeneic hematopoietic stem cell transplantation, interferon therapy, and, more recently, also therapy with the tyrosine kinase inhibitor imatinib, have entered clinical practice. The impact of these advances on long-term survival on the population level should be disclosed as timely as possible. We ...

Acquired severe aplastic anemia is a rare disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. Transplantation of these cells from unrelated donors is a treatment option frequently offered to patients after failed immunosuppressive therapy. The aim was to investigate the outcome of these patients treated with unrelated donor transplants. Systematic lite...

This paper presents a new mathematical model for a bi-objective job shop scheduling problem with sequence-dependent setup times that minimizes the weighted mean completion time and the weighted mean tardiness time. For solving this multi-objective model, we develop a fuzzy multi-objective linear programming (FMOLP) model. In this problem, a proposed FMOLP method is applied with respect to the o...

due to project evaluation complexity and resource constraints, the project portfolio optimization is numerous decision making challenges. hence, many researches have been done to introduce model and methods for portfolio optimization. but most of them have not considered the interaction between projects. considering the interactions between projects increase complexity of portfolio optimization...

an estimation problem of the mean µ of an inverse gaussian distribution ig(µ, c µ) with known coefficient of variation c is treated as a decision problem with entropy loss function. a class of bayes estimators is constructed, and shown to include mrse estimator as its closure. two important members of this class can easily be computed using continued fractions

In this research, the multi-objective project management decision problem with fuzzy goals and fuzzy constraints are considered. We constitute α-cut approach and two various fuzzy goal programming solution methods for solving the Multi-Objective Project Management (MOPM) decision problem under fuzzy environments. The Interactive fuzzy multi-objective linear programming (i-FMOLP) and Weighted Ad...

Manufacturers, who re-supply a large number of customers, continually struggle with the question of how to formulate a replenishment strategy. The purpose of this paper is to determine the optimal set of routes for a group of vehicles in the transportation network under defined constraints – which is known as the Vehicle Routing Problem (VRP) – delivering new items, and resolving the invent...