We establish a variety of combinatorial bounds on the tradeoos inherent in reconstructing strings using few rounds of a given number of substring queries per round. These results lead us to propose a new approach to sequencing by hybridization (SBH), which uses interaction to dramatically reduce the number of oligonucleotides used for de novo sequencing of large DNA fragments, while preserving ...

neuroblastoma is the most common extracranial solid tumor in children. the co- occurrence of neuroblastoma and acute lymphoblastic leukemia is rare. we report a rare case of advanced-stage neuroblastoma in a 3.5-year-old girl that was accompanied by acute lymphoblastic leukemia following treatment. her leukemia may have been due to chemotherapy (secondary leukemia) or may have been de novo.

A 53-year-old woman developed a de novo aneurysm after contralateral internal carotid artery occlusion, and another 42-year-old woman developed a de novo aneurysm after contralateral vertebral artery occlusion. Both patients experienced a rapid development of de novo aneurysm formation, 6 and 9 months, respectively. The development of de novo aneurysm on the contralateral artery after parent ar...

Prions are responsible for a heterogeneous group of fatal neurodegenerative diseases. They occur in three forms - sporadic, genetic, or acquired - and involve non-covalent post-translational modifications of the cellular prion protein (PrP(C)). Prions (PrP(Sc)) are characterized by their infectious properties and intrinsic ability to act as a template, converting the normal, physiological PrP(C...

Material Supplemental http://genesdev.cshlp.org/content/suppl/2014/07/16/28.14.1544.DC1.html References http://genesdev.cshlp.org/content/28/14/1544.full.html#ref-list-1 This article cites 36 articles, 10 of which can be accessed free at: License Commons Creative . http://creativecommons.org/licenses/by-nc/4.0/ at Creative Commons License (Attribution-NonCommercial 4.0 International), as descri...

Mass spectrometry (MS) in combination with a fragmentation technique is the method of choice for analyzing small molecules in high throughput experiments. The automated interpretation of such data is highly non-trivial. Recently, fragmentation trees have been introduced for de novo analysis of tandem fragmentation spectra (MS), describing the fragmentation process of the molecule. Multiple-stag...

Polymorphism data can be used to identify loci at which a beneficial allele has recently gone to fixation, given that an accurate description of the signature of selection is available. In the classical model that is used, a favored allele derives from a single mutational origin. This ignores the fact that beneficial alleles can enter a population recurrently by mutation during the selective ph...

Entry in Telecommunication: Customer Loyalty, Price Sensitivity and Access Prices* The purpose of this article is to investigate the prospects for entry into an existing network in the telecommunication industry, and how public policy may promote a more competitive outcome. We apply a model that captures the fact that the incumbent has an installed base of loyal consumers, that some consumers a...