Glutaric acidemia type I (GA-I) is an inherited metabolic disease characterized by accumulation of glutaric acid (GA) and striatal degeneration. Although growing evidence suggests that excitotoxicity and oxidative stress play central role in the neuropathogenesis of this disease, mechanism underlying striatal damage in this disorder is not well established. Thus, we decided to investigate the i...

Renal cell carcinoma remains one of the most common malignant tumorsand is associated with significant challenges in drug therapy. Zinc has been reported to be pharmacological importance and immense potential inhibition renal cells. In order investigate inhibitory effect zinc on human line A498, its anti-proliferative activity was investigated using CCK8 assay. The oxidative stress status mitoc...

This paper presents a detailed chemical and toxicological characterization of the diesel particulate matter (PM) emitted from vehicles running on chassis dynamometer under different driving conditions. Chemical analyses were performed to characterize contents organic carbon (OC), elemental (EC), 31 polycyclic aromatic hydrocarbons (PAHs) in collected PM samples. The OC–EC analysis results revea...

Purpose: To investigate the role of embelin in periodontal ligament stem cells (PDLSCs) an vitro model periodontitis.Methods: Lipopolysaccharide (LPS)-stimulated PDLSCs was used to construct a periodontitis cell model. treatment group were pretreated with different concentrations Embelin, and CCK-8 TUNEL staining analyze viability apoptosis. Enzyme-linked immunosorbent assay (ELISA) kits evalua...

The effect of chronic As exposure in brain, the specific oxidants production and oxidative stress still needs more attention. In present study, male wistar rats were chronically exposed to bythe drinking water during 60 days. receiving a dose 10 mg As/l showed 9- 18-fold increase content blood respectively, as compared control group. Histopathological changes detected brain samples isolated fro...

Abstract Objectives Cancer chemotherapeutic treatments come with many adverse effects. Anticancer studies natural products have been carried out to minimize these issues. This study aimed evaluate the anticancer potential of endemic Phlomis brevibracteata Turrill against four different Hepatocellular Carcinoma (HCC) cell lines and find new candidates for cancer treatment. Methods The chemical c...

The beneficial photocatalytic properties of UV light activated TiO2 powder are well-known and have been demonstrated with various pollutants pathogens. However, traditionally observed activity visible pristine is insignificant but there a few studies which reported that under some specific conditions commercially available could at least partially disinfect microorganisms even light. To better ...

Myocardial infarction is a serious representation of cardiovescular disease, MicroRNAs play role in modifying I/R injury and myocardial infarct remodeling. The present study therefore examined the potential miR-187 cardiac its underlying mechanisms. was inhibited or overexpressed cardiomyocytes H/R models by pretreatment with mimic inhibitor to confirm function H/R. DYRK2 inhibitor. A myocardiu...

objective(s):the neuroprotective effect offruit aqueous extract of ziziphus jujuba lam on glucose-induced neurotoxicity in pc12 cells as an appropriate in vitro model of diabetic neuropathy was investigated. materials and methods: cell viability was determined by the mtt assay. cellular reactive oxygen species (ros) generation was measured by dcfh-da analysis. cleaved caspase-3, a biochemical p...

An increase of oxygen saturation within blood bags and metabolic dysregulation occur during storage red cells (RBCs). It leads to the gradual exhaustion RBC antioxidant protective system and, consequently, a deleterious state oxidative stress that plays major role in apparition so-called lesions. The present study describes use test (called TSOX) based on fluorescence label-free morphology read...