Although Parkinson's disease (PD) is characterized primarily by loss of nigrostriatal dopaminergic neurons, there is a concomitant loss of norepinephrine (NE) neurons in the locus coeruleus. Dopaminergic lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are commonly used to model PD, and although MPTP effectively mimics the dopaminergic neuropathology of PD in mice, it fail...

Fifty-six patients with essential hypertension and 29 normotensive controls were hospitalized and volume expanded with saline or volume depleted with furosemide. We measured plasma norepinephrine (NE) and dopamine-f#-hydroxylase (DBH) to evaluate their sympathetic nervous activity. NE and DBH levels and their response to volume changes were the same in normal and hypertensive subjects. Volume d...

Abstract. Dey T, Ahmed S, Islam MA. 2021. Relationships of tree height-diameter at breast height (DBH) and crown diameter-DBH Acacia auriculiformis plantation. Asian J For 5: 71-75. Measuring the diameter in field is time-consuming needs more logistical efforts. Thus, this study, we have focused on evaluating relationship between with commonly less effortlessly measured parameters such as to re...

Madden, Christopher J., Satoru Ito, Linda Rinaman, Ronald G. Wiley, and Alan F. Sved. Lesions of the C1 catecholaminergic neurons of the ventrolateral medulla in rats using anti-DbH-saporin. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1063–R1075, 1999.— Phenylethanolamine-N-methyltransferase (PNMT)-containing neurons in the rostral ventrolateral medulla (RVLM) are believed ...

Norepinephrine (NE) and epinephrine (Epi) help maintain normal blood glucose levels by stimulating glucagon release, glycogenolysis, and food consumption, and by inhibiting insulin release. The absence of NE and Epi in dopamine beta-hydroxylase-null (Dbh-/-) mice results in chronically low blood glucose levels, an impaired glucagon response to hypoglycemia, and elevated insulin levels. Neverthe...

During development, the sympathetic neurons innervating sweat glands undergo a neurotransmitter switch from noradrenergic to cholinergic between postnatal day (P) 4, when the sympathetic neurons first contact the sweat glands, and P21. Several in vitro experiments suggest that norepinephrine (NE), produced by sympathetic neurons, stimulates sweat glands to produce a factor that then induces the...

Abstract: The objectives of this study were to analyze diameter growth in relation to natural thinning in high-density stands in even-aged, pure plantation forests and to develop a growth prediction system based on Japanese permanent plot data. Long-term data recorded in even-aged, pure, unthinned stand plots of Sugi (Cryptomeria japonica) forests were available. Relationships between log-trans...

Norepinephrine (NE) is thought to play an important role in the pathophysiology of depression, and in the mechanism of action of antidepressant compounds. Previously, we created mice that are unable to synthesize NE and epinephrine due to targeted disruption of the dopamine-beta-hydroxylase gene (Dbh). To specifically test the role of NE in mediating behavioral changes elicited by antidepressan...

BACKGROUND Human dopamine β-hydroxylase (DBH) is an important therapeutic target for complex traits. Several single nucleotide polymorphisms (SNPs) have also been identified in DBH with potential adverse physiological effect. However, difficulty in obtaining diffractable crystals and lack of a suitable template for modeling the protein has ensured that neither crystallographic three-dimensional...