نتایج جستجو برای: dantrolene
تعداد نتایج: 683 فیلتر نتایج به سال:
BackgroundAlcohol and caffeine are the 2 frequently consumed substances in general population co-consumed. Both may increase cardiac arrhythmia risk. However, it is unknown whether alcohol co-consumption can synergistically enhance arrhythmogenesis.ObjectiveTo investigate binge drinking affect arrhythmogenesis.MethodsA rat model (alcohol 2g/kg, IP, every other day for 3 times) was used. Rats (4...
To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx). MK-801 or dantrolene, but not FK506, suppressed convulsive seizures in EL mice; only MK-801 reduced NOx in the brain. Our results suggest...
In 25 patients with spasticity, pharmacokinetics and effects of dantrolene sodium were investigated after prolonged administration. A beneficial effect occurred in seven patients. The results were better on 100 mg daily than on a higher daily dose. An increase of the daily dose from 200 to 400 mg was not associated with higher blood levels. Many side effects were noted such as: anorexia, nausea...
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