DNA adenine methyltransferase (Dam) plays an important role in physiological processes of Gram-negative bacteria such as mismatch repair and replication. In addition, Dam regulates the expression of virulence genes in various species. The authors cloned the dam gene of Yersinia enterocolitica and showed that Dam is essential for viability. Dam overproduction in Y. enterocolitica resulted in an ...

The design and construction of water resource management systems, including tidal dams or barrages, requires careful planning, in part because of the engineering complexity associated with large civil works, and in part because they are situated within the much larger, complex coastal environment. The combined engineering and environmental complexities associated with these systems mean that fa...

BACKGROUND Decision-analytic modelling (DAM) has become a widespread method in health technology assessments (HTA), but the extent to which modelling is used differs among international HTA institutions. In Germany, the use of DAM is optional within HTAs of the German Institute of Medical Documentation and Information (DIMDI). Our study examines the use of DAM in DIMDI HTA reports and its effec...

DNA adenine methylase (Dam(-)) mutants of Salmonella enterica are attenuated in the mouse model and present multiple virulence-related defects. Impaired interaction of Salmonella Dam(-) mutants with the intestinal epithelium has been tentatively correlated with reduced secretion of pathogenicity island 1 (SPI-1) effectors. In this study, we show that S. enterica Dam(-) mutants contain lowered l...

Tailings dams, due to methods and materials used in their construction are vulnerable structures to earthquake. In many cases storage of water over tailings is required to prevent aerial pollution or reduction in water consumption by the means of a recycling system, therefore failure of these kinds of dams not only induce affects similar to conventional water dams, but also may lead to irrevers...

Vortex formation due to power generation at hydropower dams could cause serious problems, and eliminating or reduction in its strength is one of the dam designer and manager duties. Therefore, the design and use of anti-vortex structures is usual. Design of an anti-vortex structure for each project is unique and it is therefore necessary to have knowledge about the performance of each one. In t...

ABSTRACT: An efficient method is proposed to find optimal design of arch dams on the basis of constrained natural frequencies utilizing continuous evolutionary algorithm. To extract natural frequencies of arch dam considering fluid-structure interaction, it is necessary to solve the unsymmetrical damped eigenproblem. This means that the process of natural frequencies extraction may impose much ...

Total fatty acid composition of muscle lipids in some fish species (Cyprinus carpio (Işıklı Dam Lake), Tinca tinca (Işıklı Dam Lake), Scardinius erythrophthalmus (Işıklı Dam Lake), Cyprinus carpio (Karacaören Dam Lake), and Carassius carassius (Karacaören Dam Lake)) was determined by gas chromatography. Polyunsaturated fatty acids (PUFAs) of Cyprinus carpio (Işıklı Dam Lake) were found higher t...

This paper proposes and validates a new formulation on the dynamic response of dam-reservoir system, including water compressibility, absorption of the boundary of the reservoir, the earthquake excitation from different directions and the radiation condition boundary at infinity. The impounded water is modeled by Scaled Boundary Finite Element Method, and discretization only at the boundary coi...

A collaborative virtual geographic environment (CVGE) is a 3-D, distributed, and graphical world representing and simulating geographic phenomena and processes to enable geographically distributed users to explore geoproblems and theories and generate hypotheses, and to support geomodel building and validation and collaborative ecological planning. This chapter reports an approach to establishi...