A new power-efficient, reconfigurable, 6-order continuous-time bandpass delta-sigma modulator architecture is presented. A new duty-cycle-controlled DAC halves the number of DACs in the modulator, and also enables the center frequency to be reconfigurable. A prototype 800MS/s modulator achieves 69dB SNDR with a 25MHz bandwidth at a 200MHz IF. The center frequency can be varied from 180MHz to 22...

PURPOSE To investigate the anchoring of plasmid DNA/anti-DNA antibody/cationic lipid tri-complex (DAC micelles) onto bisphosphonate-modified 316 L coronary stents for cardiovascular site-specific gene delivery. METHODS Stents were first modified with polyallylamine bisphosphonate (PAA-BP), thereby enabling the retention of a PAA-BP molecular monolayer that permits the anchoring (via vector-bi...

Epigenetic variation represents a mechanism of regulation for genes expressed in different cancer histotypes. We considered breast cancer, and investigated differential expression following treatment with the 5-Aza-2'deoxycytidine or DAC, a demethylating agent. Several oncogenic signalling pathways altered upon DAC treatment were detected with significant enrichment, and a regulatory map integr...

1. As part of its ongoing work programme the OECD Development Cooperation Directorate is conducting a review on managing and measuring for results among DAC members and observers. An online survey was launched to which DAC members’ and observers’ results managers and specialists were invited to contribute. The objective of this online survey was to get a snapshot on where DAC members and observ...

PURPOSE Azanucleoside DNA methyltransferase (DNMT) inhibitors are currently approved by the U.S. Food and Drug Administration for treatment of myelodysplastic syndrome. The relative contributions of DNMT inhibition and other off-target effects to their clinical efficacy remain unclear. Data correlating DNA methylation reversal and clinical response have been conflicting. Consequently, it is nec...

BACKGROUND A cell line with transfected Wilms' tumor protein 1 (WT1) is has been used for the preclinical evaluation of novel treatment strategies of WT1 immunotherapy for leukemia due to the lack of appropriate murine leukemia cell line with endogenous WT1. However, silencing of the transgene occurs. Regarding the effects of hypomethylating agents (HMAs) on reactivation of silenced genes, HMAs...

Developmental processes such as morphogenesis, patterning and differentiation are continuously active in the adult Hydra polyp. We carried out a small molecule screen to identify compounds that affect patterning in Hydra. We identified a novel molecule, DAC-2-25, that causes a homeotic transformation of body column into tentacle zone. This transformation occurs in a progressive and polar fashio...

Linearity is a critical measurement for overall performance of digital-to-analog converters (DAC) in mixed-signal system-on-chips (SoCs). Device parameters become more difficult to control due to variations from fabrication process with deep sub-micron technology. Such parameters also continue to degrade after fabrication as time elapses. Process variations of DACs are major source of non-linea...

An isolable N,N’-diamidocarbene (DAC) was previously shown to promote the B–H bond activation of various BH3 complexes. The resultant DAC–BH3 adducts facilitated olefin hydroborations under mild conditions and in the absence of exogenous initiators. The substrate scope for such transformations was further explored and is described herein. While organoboranes were obtained in quantitative yields...