It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is commonly used as internal standard for 1,25D liquid chromatography-mass spectrometry (LC-MS) quantification. In the present study using human breast cancer cell lines, the biolo...

Plasma and lipoprotein a-tocopherol concentrations of four patients with familial isolated vitamin E deficiency and six control subjects were observed for 4 d after an oral dose (15 mg) of RRR-a-tocopheryl acetate labeled with six deuterium atoms (d6-tocopherol). Chylomicron d6-tocopherol concentrations were similar in the two groups. d6-Tocopherol concentrations of plasma, very low (VLDL), low...

We find the complete classical moduli space of two-centered supersymmetric solutions carrying D0 and D6 brane charge in the STU model delimited by walls of marginal stability of co-dimension one. U-duality guarantees our conclusions hold for any BPS state with negative quartic invariant. The analysis explicitly shows that the conditions of marginal stability, i.e. the integrability conditions, ...

We investigate degeneracies of BPS states of D-branes on compact Calabi-Yau manifolds. We develop a factorization formula for BPS indices using attractor flow trees associated to multicentered black hole bound states. This enables us to study background dependence of the BPS spectrum, to compute explicitly exact indices of various nontrivial D-brane systems, and to clarify the subtle relation o...

Before trust negotiation framework can be used in practice, researchers should give several kinds of guarantees including the following: • Are negotiations going to succeed when the policies in principle allow it? The answer is not trivial, because in some cases the policies are protected as sensitive resources, and this may prevent peers from explaining exactly what is needed to complete the n...

Chemokines and their receptors are key regulators of leukocyte migration and intra-tissue accumulation under both homeostatic and inflammatory conditions. Regulation of chemokine-dependent responses, particularly those relating to inflammation, is essential to avoid the development of inflammatory and autoimmune pathologies. Recently, a new subfamily of chemokine receptors referred to as the 'a...

We study the dyonic charge of type IIA D6-branes interpreted as M-theory Kaluza-Klein monopoles. The connection between the dyonic properties of type IIA D6-branes and the existence of eleven dimensions is discussed. We also study dyonic properties of noncommutative monopoles. Variations of the external antisymmetric B-field generate the electric charge of non-commutative dyons. E-mail: cesar.g...

For a given attractor black hole with generic D6-D4-D2-D0-charges in four dimensions we identify the set of supersymmetric branes, static or stationary in global coordinates, of the corresponding eleven-dimensional near horizon geometry. The set of these BPS states, which includes branes which partially or fully wrap the horizon, should play a role in understanding the partition function of bla...

Emergence of artemisinin resistance in Cambodia highlights the importance of characterizing resistance to this class of drugs. Previously, intermediate levels of resistance in Plasmodium falciparum were generated in vitro for artelinic acid (AL) and artemisinin (QHS). Here we expanded on earlier selection efforts to produce levels of clinically relevant concentrations, and the resulting lines w...