Pulmonary vascular responses to leukotriene D4 were investigated in the intact-chest animal under conditions of controlled pulmonary blood flow. Intralobar injections of leukotriene D4 in the sheep caused dose-dependent increases in lobar arterial and small vein pressures without influencing left atrial or systemic arterial pressure. Leukotriene D4 was very potent in increasing pulmonary vascul...

In this paper, the silicon-containing sulfonated polystyrene/acrylate–ionic liquid (Si-SPS/A–IL)hybrid membranes was prepared to obtain the proton exchange membrane (PEM) materials withhigh methanol barrier and good selectivity. The Si-SPS/A–IL hybrid membranes characterized asthe function of IL to evaluate their potential as PEMs in direct methanol fuel cells (DMFCs).Fourdifferent Hybrid mater...

background: although many experimental studies provide convincing evidence that type ii immunity is protective against helminths, recent data in mice demonstrate that th1 is also impor-tant in some cestodes like hymenolepis nana. objective: to identify the role of th1 and th2 lymphocytes in immunity against h. nana, the levels of il-12, ifnγ, il-5, and il-13 were de-termined in serum of humans ...

Airborne transmission of Pneumocystis carinii has been established, but the infective form and the sources of infection remain unknown. Animal models for studies of P. carinii have previously been limited to immunosuppressed rodents; however, this study was performed with nonimmunodepressed P. carinii-free rabbits. This study was aimed at determining (i) the delay between inoculation of animals...

For the large and chemically diverse GMTKN55 benchmark suite, we have studied performance of density-corrected density functional theory (HF-DFT), compared to self-consistent DFT, for several pure hybrid GGA meta-GGA exchange-correlation (XC) functionals (PBE, BLYP, TPSS, SCAN) as a function percentage HF exchange in hybrid. The D4 empirical dispersion correction has been added throughout. subs...

quercetin is a dietary flavonoid which has anti-inflammatory effects. this study aimed to evaluate the influence of quercetin on histopathological aspects and airway epithelium in  allergic airway  inflammation mice model. twenty-eight balb/c mice were randomly divided into four groups: group i (control), group ii (untreated mice with allergic airway inflammation), group iii (allergic airway in...

To characterize the influences of leukotriene D4 on regional vascular smooth muscle, effects of leukotriene D4 on vasomotor tone of canine renal and superior mesenteric arterial rings were determined. Vascular smooth muscle tone was measured with isometric force transducers. After tone had been induced with norepinephrine, leukotriene D4, in concentrations of 10(-8) M to 10(-7) M, produced dose...

A pharmacophore model for dopamine D4 antagonists has been developed on the basis of a previously reported dopamine D2 model. By using exhaustive conformational analyses (MM3* force field and the GB/SA hydration model) and least-squares molecular superimposition studies, a set of eighteen structurally diverse high affinity D4 antagonists have successfully been accommodated in the D4 pharmacopho...