New rapid phenotypic assays for the detection of rifampin resistance in Mycobacterium tuberculosis have recently been described, but most of these require liquid cultures, which reduces the utility of many tests in terms of turnaround times. In the United Kingdom, over 90% of rifampin-resistant isolates are also resistant to isoniazid, so rifampin resistance can be used as a sensitive marker fo...

Patients with acute lymphoblastic leukaemia (ALL) are at high venous thromboembolism (VTE) risk (affecting between 1.5 and 37%) with up to 50% affecting the cerebral veins. Thrombosis is a potentially avoidable source of morbidity and mortality in ALL patients, particularly during the early phases of chemotherapy. Prevention and treatment of thrombosis with antithrombotic drugs may be complicat...

OBJECTIVES HIV-1 protease inhibitors (PIs) are key components of HIV therapy. PL-100 is a novel lysine sulphonamide that demonstrates potent antiviral activity against multiresistant HIV-1 strains as well as a higher genetic barrier for development of resistance mutations compared with first-generation PIs. In the present study, we compared the antiviral activity of PL-100 against HIV-1 subtype...

due to contiguous city of ravar with lut and dasht-e kavir desert, and weather conditions, water is one of the rarest agricultural inputs in this city. pistachio allocates 90% of garden and 73% of agricultural lands of the city and it is the most important agricultural product in this region. a major source of agricultural water supply in this area is groundwater. low price of water on one side...

TMC114, a newly designed human immunodeficiency virus type 1 (HIV-1) protease inhibitor, is extremely potent against both wild-type (wt) and multidrug-resistant (MDR) viruses in vitro as well as in vivo. Although chemically similar to amprenavir (APV), the potency of TMC114 is substantially greater. To examine the basis for this potency, we solved crystal structures of TMC114 complexed with wt ...

Conventional treatment of esophageal cancer with surgery or radiation alone has afforded few long-term survivors. In order to improve outcome and determine the efficacy of a combined modality approach, this prospective study was performed. Between May 1993 and August 1994, 27 patients with loco-regional squamous cell carcinoma of the esophagus were treated with 2 courses of combined fluorouraci...

Cancer is the second leading cause of death worldwide, with breast cancer one tumors highest incidence in Brazil, an estimated 57,120 new cases 2014. Several forms treatment and control symptoms has been studied, among them homeopathy. In Banerji clinic India, doctors have used a protocol consisting 4 homeopathic medicines relevant results that motivated this study. our research Ehrlich tumor w...