centralizing and using proper transportation facilities cut down costs and traffic. hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. a distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...

D-optimality is one of the most commonly used design criteria for linear regression models. In industrial experiments binary or count data often arise, for example defective/nondefective or number of defects. For such data Generalized Linear Models (GLMs) are appropriate. An analogous D-optimality design criterion can be developed using the asymptotic covariance matrix. For GLMs, this matrix is...

In this study, we developed and optimized a self-microemulsifying drug delivery system (SMEDDS) formulation for improving the dissolution and oral absorption of atorvastatin calcium (ATV), a poorly water-soluble drug. Solubility and emulsification tests were performed to select a suitable combination of oil, surfactant, and cosurfactant. A D-optimal mixture design was used to optimize the conce...

Importance sampling involves approximation of functionals (such as expectations) of a target distribution by sampling from a design distribution. In many applications, it is natural or convenient to use a design distribution which is a mixture of given distributions. One typically has wide latitude in selecting the mixing probabilities of the design distribution. Furthermore, one can reduce var...