1130, page 191A.45. Dagan R, Melamed R, Abramson O, Piglansky L, Greenberg D, Mendelman P, et al. Effect ofheptavalent pneumococcal-OMPC conjugate vaccine on nasopharyngeal carriage when administeredduring the 2nd year of life. Presented at the Annual Meeting of the American Pediatric Society/Society forPediatric Research, San Diego, CA, 1995; Abstract #1020, page 172A.46. S...

BACKGROUND Cancer cachexia is associated with increased pro-inflammatory cytokine levels. Centella asiatica (C. asiatica) possesses antioxidant, anti-inflammatory and anti-tumour potential. We investigated the modulation of antioxidants, cytokines and cell death by C. asiatica ethanolic leaf extract (CLE) in leukaemic THP-1 cells and normal peripheral blood mononuclear cells (PBMC's). METHODS...

introduction: d-galactose (d-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. in the present study, we selected crocin, the main constituent of crocus sativus l. (saffron), against d-gal cytotoxicity in human neuroblastoma sh-sy5y cells. materials and methods:  cells were pretreated with crocin (25-500 µm) for 24 h and then exposed to d-gal...

The effect of fasting for 12, 36 and 72 h was studied in twenty-nine healthy subjects (seventeen women and twelve men). Measurements were made of cardiovascular variables, metabolic rate, respiratory exchange ratio, plasma metabolites, insulin, thyroid hormones and catecholamines. During starvation there were no significant changes in blood pressure, whilst heart rate (beats/min) increased at 3...

PURPOSE To evaluate in vitro the effect of nerve growth factor (NGF) on the differentiation of mouse corneal limbal progenitor cells into goblet cells and to observe the expression of mucin-5AC (MUC5AC) mRNA. METHODS Mouse limbal epithelial cells were cultured in a 1:1 mixture of Dulbecco's modified Eagle's medium/Ham's nutrient mixture F12 in vitro, and 63-kDa protein (p63) in cultured cells...

Growing evidence indicates chronic low-grade systemic inflammation as a major pathophysiological mechanism of obesity. Systemic provokes an immune response in the brain through activation microglia that results development neuroinflammation, cellular senescence, and occurrence neurological dysfunction. In efforts to identify innovative intervention with potential efficacy on obesity associated ...

pumpkin, as a dietary plant, has been used in traditional medicine around the world. in addition, during the last decade, antidiabetic, antihypertensive, antitumor, intestinal antiparasitic, antibacterial, anti hypercholesterolemia, anti-inflammatory, immunomodulatory and analgic effects of pumpkin has been reported. the aim of the present study was to determine the effects of different extract...

We compared plasma maximum concentration (Cmax) and area under the concentration-time curve (AUC) of the antimalarial drug piperaquine in 26 healthy Vietnamese subjects after treatment with either a single oral dose of 500 mg (n = 6) or 1,000 mg (n = 6) of piperaquine phosphate and a three-day course of 500 mg of piperaquine/ day in the fasting state (n = 7) or with food (approximately 17 g fat...