Hirschsprung's disease (HSCR), a frequent developmental defect of the enteric nervous system is due to loss-of-function mutations of RET, a receptor tyrosine kinase essential for the mediation of glial cell-derived neurotrophic factor (GDNF)-induced cell survival. Instead, gain-of-function Cys mutations (e.g., Cys(609), Cys(620), and Cys(634)) of the same gene are responsible for thyroid carcin...

The purpose of this study was to determine the predictive value of IL-6-572, -190, and -634 gene polymorphisms on the cachexia susceptibility and survival time of patients with pancreatic cancer. Genotypes were determined using restriction fragment length polymorphism analysis of polymerase chain reaction products. All of the subjects were homozygous to the C allele of IL-6-190. No significant ...

In a previous study, we generated two monoclonal antibodies (mAbs) in mice, aNogoA-N and aNogo-66 mAb, which were raised against recombinant N-terminal fragments of rat NogoA and Nogo-66, respectively. When compared with the commercial rabbit anti-rat NogoA polyclonal antibody (pAb), which can specifically recognise NogoA, the two mAbs were also specific for the NogoA antigen in immunofluoresce...

The replication and transcription activator (RTA) of Kaposi's sarcoma-associated herpesvirus (KSHV), K-RTA, is a lytic switch protein that moderates the reactivation process of KSHV latency. By mass spectrometric analysis of affinity purified K-RTA, we showed that Thr-513 or Thr-514 was the primary in vivo phosphorylation site. Thr-513 and Thr-514 are proximal to the nuclear localization signal...

BACKGROUND Reports on pediatric electroencephalogram of Nepalese patients are rare. OBJECTIVE We aimed to study the relationship between provisional clinical and electrophysiological diagnoses of pediatric patients with documentation of demographic profiles, and type and frequency of the disorders/diseases. METHODS Electroencephalographic reports of 634 children from 2006 to 2009 were analy...

The objective: to determine the frequency of resistance Mycobacterium tuberculosis (MTB) most effective anti-tuberculosis drugs in patients Republic Karelia, characterize cases amplification MTB drug during chemotherapy (CT). Subjects and Methods. cultures 1,137 were studied, received from 2016 2021, among them 634 (55.8%) had multiple (MDR). Among MBT with MDR, there was a high extensive (XDR)...

Connu pour ses recherches sur la poesie persane et avoir fait connaitre le Dīwān de plus celebre poetesse iranienne, Jahān-Malik-Khātūn, Dominic Parviz Brookshaw s’interesse dans cet ouvrage a Ḥafiẓ (m. 1390) une perspective comparatiste. Il etudie les ghazals du poete Chiraz en prenant compte œuvres ceux qui lui etaient contemporains, tout particulierement Khwājū Kirmānī 1362 ou 1361), ‘Ubayd-...

BACKGROUND Previous studies demonstrated that the vascular endothelial growth factor (VEGF) was being implicated in the airways inflammation and remodeling process in patients with asthma. AIMS We explored the relationship of three polymorphisms in the VEGF gene with asthma in both case control and family studies. METHODS We Genotyped a total of 210 children with asthma, 224 unrelated contr...

Discussing Suhrawardi, certainly, cannot be separated from his concept of thinking about illumination (hikmah isyrâqiyya), which has contributed to the foundation human knowledge and awareness. The research question in this paper is how esotericism Shihabuddin Suhrawardi’s Sufism relates philosophy Illumination. discussion study based on qualitative library research. In each section, supplement...