this study investigated the cytochemical responses in hediste diversicolor exposed to the environmental concentrations of cadmium (1µm cd), copper (1µm cu) and to their equimolar mixture for 48h. lysosomal membrane stability (lms), neutral lipids (nl) level, lipofuscin (lf) content and ca2+-atpase activity were determined as early subcellular biomarkers of toxicity. the biomarker battery pointe...

cancer is considered as a challenging deathly disease and discovering or synthesis of new cytotoxic agents is a worldwide attempt. in this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having differesnt cox-1 and/or cox-2 selectivities, have been examined on human hepatocarcinoma (hepg2), lung carcinoma (a549), and breast adenocarcinoma (mcf-7...

three new complexes of formula [pd(bpy)(r-nh-css)] cl (where bpy is 2/2′- bipyridine, and r-nh-css is butylamine, hexylamine- and octyamine-dithiocabamate anion) have been synthesized by university of sistan and blachostan. these complexes have been characterized by spectroscopic methods such as ultraviolet-visible, infrared and 1h-nmr as well as conductivity measurements and chemical analysis....

objective(s): nanomaterials, especially silver nanoparticles (ag-nps), are employed in an increasing number of commercial products. this has led to an ever growing exposure of human beings to this substance. the first purpose of the nano committee of food and drug administration of the islamic republic of iran (ifda) is developing guidelines to assess and approve commercial nano-health products...

the antioxidant and cytotoxic properties of four major parts of methanolic extracts of tephrosia purpurea including leaves, root, stem and seed were investigated and compared. in vitro antioxidant activity of t. purpurea extracts was evaluated using 1,1-diphenyl-2-picrylhydrazyl (dpph), ferric reducing antioxidant power (frap), reducing power assay and antihemolytic assay. in vitro cytotoxic ef...

studies on biomedical applications of nanoparticles are growing with a rapid pace. in medicine, nanoparticles may be the solution for multi-drug-resistance which is still a major drawback in chemotherapy of cancer. in the present study, we investigated the potential cytotoxic effect of silver nanoparticles (ag nps) and silver ions (ag+) in both parent and tamoxifen-resistant t47d cells in prese...

it has been recognized that acute and chronic stress has an impact on the immune system. acute stress may have a stimulating effect on the immune system, while in the case of chronic stress specially depression, the immune system could be down-regulated. however, an association between depression and a higher number of circulating white blood cells with increased activity has been reported. ele...

dacarbazine (dtic) is a synthetic chemical antitumor agent which is used to treat malignant melanoma and hodgkin’s disease. dtic is a prodrug which is converted to an active form undergoing demethylation by liver enzymes. the active form prevents the progress of disease via alkylation of dna strand. in the structure of this drug, the imidazole ring, a triazen chain and carboxamide group exist. ...

the biological application of nanoparticles (nps) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. the cytotoxicity was evaluated by mtt and ldh assays. the apoptotic effect of free icd-85 and icd-85 nps on hela cells was assessed using caspase-8 colorimetric assay. the mtt assay showed that icd-85 nps could enhance the in-vitro cyt...

Direct cytotoxicity and antibody dependent cell mediated cytotoxicity against Giardia lamblia trophozoites exhibited by splenic, intraepithelial and lamina propria lymphocyte populations isolated from G lamblia infected mice were studied. Different patterns of cytotoxicity were found. Intraepithelial lymphocytes showed a direct cytotoxic activity of 20.6 +/- 5.6% before infection. It was signif...