نتایج جستجو برای: cytochrome p450
تعداد نتایج: 52079 فیلتر نتایج به سال:
Several heterocyclic amines, found in cooked food, are powerful mutagens in the Ames Salmonella mutagenicity test system. One of these, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) is one of the most mutagenic chemicals tested in this assay. In primary cultures of chick and rat hepatocytes, MeIQ, by itself, induced cytochrome P450 from the IA subfamily but was a weak inducer compared to 3...
Quinones are widely distributed in nature, and some quinone compounds are used as therapeutic agents such as anti-cancer, anti-malarial or anti-bacterial drugs. However, their therapeutic use is limited in some cases because the use of most quinones is accompanied by adverse effects derived from their cytotoxicity, especially for hepatocytes. Two mechanisms have been proposed to explain quinone...
Microbial transformation is an essential component for the commercial production of numerous valuable steroid drugs such as hydrocortisone, prednisolone. Steroid hydroxylation at C11 and C15 positions by filamentous fungi is routinely employed in the steroid industry due to both the necessity of regioand stereoselective oxyfunctionalization of unactivated C-H bonds of valuable steroid compounds...
Ethylene (74-85-1) is an important petrochemical and is produced endogenously. It is metabolized to ethylene oxide (EO) by cytochrome P450. We studied the inhibition of cytochrome P450 activity during exposure to ethylene, and verified that this inhibition was reflected in the concentration of EO in the blood. Male F344 rats were exposed to 1000, 600, and 300 ppm ethylene by nose-only inhalatio...
Dichloromethane (DCM) is a volatile halogenated hydrocarbon with teratogenic, mutagenic and carcinogenic effects. Biodegradation generally regarded as an effective economical approach of pollutant disposal. In this study, novel strain was isolated its cytochrome P450 heterologously expressed for DCM degradation. The isolate, Microbacterium keratanolyticum ZY, characterized Gram-positive, rod-sh...
Mammals express multiple cytochromes P450 simultaneously in a variety of tissues, including the liver, kidney, lung, adrenal, gonads, brain, and most others. For cytochromes P450 that are expressed in many tissues or cell types, the tissue/cell type-specific expression might be associated with their special physiological roles. Several cytochrome P450 enzymes are found not only in different cel...
Proteoliposomes, containing cytochrome P450 1A2, were obtained by the cholate-dialysis technique. The effect of bifunctional cross-linking reagents on the purified hexameric cytochrome P450 1A2 in an aqueous medium and on the proteoliposomal P450 1A2 have been compared. Electrophoretic analysis of the modified proteins demonstrated the same oligomeric (hexameric) organization of the hemoprotein...
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