Histone modification is known to be associated with multidrug resistance phenotypes. Cancer cell lines that are resistant or have been made resistant to anti-cancer drugs showed lower expression levels of histone deacetylase-3 (HDAC3), among the histone deacetylase(s), than cancer cell lines that were sensitive to anti-cancer drugs. Celastrol and Taxol decreased the expression of HDAC3 in cance...

Acidic residues which are found on transmembrane segments within the lactose permease may play an important role in H+ and/or sugar recognition. To examine the functional roles of Glu-269 and Glu-325, we have constructed a variety of amino acid substitutions (e.g. aspartate, glycine, alanine, serine, or glutamine) via site-directed mutagenesis. At position 269, all mutations appear to have a de...

The poliovirus RNA-dependent RNA polymerase (3Dpol) contains a region of homology centered around the amino acid motif YGDD (amino acids 326 to 329), which has been postulated to be involved in the catalytic activity of the enzyme. Previous studies from this laboratory have used oligonucleotide site-directed mutagenesis to substitute the tyrosine amino acid at this motif with other amino acids ...

Malignant glioma is the most common type of primary brain tumor in adults, characterized by rapid tumor growth and infiltration of tumor cells throughout the brain. Alterations in the activity of the 26S proteasome have been associated with malignant glioma cells, although the specific defects have not been identified. Recently, microRNA-326 (miR-326) was shown to play an important role in glio...

17.6 Open Issues of ECG Based Biometrics Applications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323 17.6.1 Lack of Standardization of ECG Fiducial Points . . . . . . . . . . . . . . 323 17.6.2 Time Variant Nature of ECG . . . . . . . . . 324 17.6.3 Pertinence of Random Abnormality in ECG. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325 17.6.4 Longer Duration for ECGWa...

BACKGROUND MicroRNAs (miRNAs) can serve as tumor suppressors and might provide an efficient strategy for annihilating tumor cells. Nevertheless, the potential role of miR-325 in hepatocellular carcinoma (HCC) is still unknown. METHODS Using RT-PCR, immunoblots invasion assays and bioinformatics strategies, we investigated the potential role of miR-325 in HCC. RESULTS We showed that miR-325 ...

http://bmj.com/cgi/content/full/325/7378/1437 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/325/7378/1437/DC1 "Figures" References http://bmj.com/cgi/content/full/325/7378/1437#otherarticles 26 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/325/7378/1437#BIBL This article cites 11 arti...

http://bmj.com/cgi/content/full/325/7363/504 Updated information and services can be found at: These include: References http://bmj.com/cgi/content/full/325/7363/504#BIBL This article cites 8 articles, 6 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/325/7363/504 You can respond to this article at: http://bmj.com/cgi/content/full/325/7363/504#responses free ...