In our continued efforts to explore the antidiabetic potential of pregnanes from Apocynaceae, especially Asclepiadoideae subfamily, sixteen derivatives 1-16 previously isolated various Cynanchum species, have been evaluated for their ability increase glucagon-like peptide-1 (GLP-1) release in a cell assay. As result, otophylloside A (2), wilfoside C1N (13), and C3N (16) were found stimulate sig...

Abstract The invasive vine black swallowwort [ Vincetoxicum nigrum (L.) Moench = Cynanchum louiseae Kartesz & Gandhi, Apocynaceae] is difficult to control, and herbicide studies are lacking. This long-lived perennial species primarily found in high-light environments natural areas cropping systems northeastern North America. We conducted a 3-yr efficacy study, with or without mowing, an old...