To ensure targeting of apoferritin nanocarrier with encapsulated doxorubicin drug, we used a peptide linker based on a protein G with N-terminus affinity towards Fc region of antibodies. To connect the peptide to the surface of apoferritin, the C-terminus of peptide was made of cysteine with affinity to gold. The surface of apoferritin with encapsulated doxorubicin (APODOX) was coated either wi...

The dispersion and manipulation of carbon nanotubes (CNTs) are of great importance if we are to utilise the unique properties of CNTs in a range of biological, electrical and mechanical applications. Recently, a designed amphiphilic peptide helix termed nano-1 has been shown to solubilise CNTs in aqueous solution. Furthermore, the peptide is capable of assembling these coated tubes into fibres....

Lantibiotics are lanthionine-containing peptide antibiotics. Nisin, encoded by nisA, is a pentacyclic lantibiotic produced by some Lactococcus lactis strains. Its thioether rings are posttranslationally introduced by a membrane-bound enzyme complex. This complex is composed of three enzymes: NisB, which dehydrates serines and threonines; NisC, which couples these dehydrated residues to cysteine...

The research of cycloparaphenylenes (CPPs), the smallest armchair carbon nanotube, has been a quest for the past decades which experienced a revival in 2008 when the first synthesis was achieved. Since then CPPs with various ring sizes have been realized. The incorporation of substituents and the synthesis of CPPs with building blocks different from phenyl rings bear challenges of their own. Su...

Aβ42 peptide binds neuronal membranes and aggregates into plaques that are characteristic of Alzheimer's disease. has been proposed to be generated in membrane (nano) domains the liquid-ordered phase, ganglioside GM1 being a major facilitator binding membrane. The exists solution various degrees aggregation, either monomers, oligomers or fibrils, which appear particularly toxic. present study r...

Gut verfügbare Derivate cyclohexa-2,5-dien-1-ylsubstituierter Acylchloride werden als lagerfähige HCl-Surrogate für Transferhydrochlorierungen von terminalen und internen Alkenen sowie ausgewählten Alkinen vorgestellt. Die schrittweise Grob-Fragmentierung jener Säurechloride in Chlorid, Kohlenmonoxid, einen niedermolekularen Aromaten ein Proton wird durch B(C6F5)3 vermittelt. Dieser decarbonyli...

Objective: to determine the effect of nano-hydroxyapatite and different bioactive remineralizing agent in treatment loss enamel minerals. Material M nano-hydroxyapatite, Casein phospho-peptide amorphous calcium phosphate Sodium Fluoride. While artificial saliva was applied on control specimens. Surface microhardness measurements baseline were calculated, before/after demineralization digital 3D...

A number of functional foods containing seaweed-derived peptides are currently commercialized. Some seaweed derived peptide-containing products include Wakame peptide® and Nori peptide S®. To develop with the addition Ulva spp. peptides, isolation identification dipeptidyl peptidase IV (DPP-IV) inhibitory from hydrolysates this was performed. were fractionated purified sequentially by anion exc...